The local physicochemical environment conditions the proinflammatory response of endothelial cells and thus modulates leukocyte recruitment

Research output: Contribution to journalArticlepeer-review

Standard

Harvard

APA

Vancouver

Author

Bibtex

@article{7f0c7795ad9549b7aa0605d637792de8,
title = "The local physicochemical environment conditions the proinflammatory response of endothelial cells and thus modulates leukocyte recruitment",
abstract = "The locations at which vascular endothelial cells recruit leukocytes during physiological or pathological inflammatory responses are influenced by direct effects of local haemodynamics on leukocyte adhesion. However, the expression of genes by endothelial cells, and their ability to respond to inflammatory cytokines also depend on the flow forces to which they are exposed. In addition, cells of the underlying stroma can modify the phenotype and responsiveness of endothelial cells, and hence their ability to recruit leukocytes. Thus, endothelial cells are plastic in their responses, and we hypothesise that the pattern of recruitment of leukocytes to tissues is critically dependent on the variable modulation of the endothelium by the local physicochemical microenvironment. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
author = "Gerard Nash and Christopher Buckley and George Rainger",
year = "2004",
month = jul,
day = "2",
doi = "10.1016/j.febslet.2004.05.040",
language = "English",
volume = "569",
pages = "13--17",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - The local physicochemical environment conditions the proinflammatory response of endothelial cells and thus modulates leukocyte recruitment

AU - Nash, Gerard

AU - Buckley, Christopher

AU - Rainger, George

PY - 2004/7/2

Y1 - 2004/7/2

N2 - The locations at which vascular endothelial cells recruit leukocytes during physiological or pathological inflammatory responses are influenced by direct effects of local haemodynamics on leukocyte adhesion. However, the expression of genes by endothelial cells, and their ability to respond to inflammatory cytokines also depend on the flow forces to which they are exposed. In addition, cells of the underlying stroma can modify the phenotype and responsiveness of endothelial cells, and hence their ability to recruit leukocytes. Thus, endothelial cells are plastic in their responses, and we hypothesise that the pattern of recruitment of leukocytes to tissues is critically dependent on the variable modulation of the endothelium by the local physicochemical microenvironment. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - The locations at which vascular endothelial cells recruit leukocytes during physiological or pathological inflammatory responses are influenced by direct effects of local haemodynamics on leukocyte adhesion. However, the expression of genes by endothelial cells, and their ability to respond to inflammatory cytokines also depend on the flow forces to which they are exposed. In addition, cells of the underlying stroma can modify the phenotype and responsiveness of endothelial cells, and hence their ability to recruit leukocytes. Thus, endothelial cells are plastic in their responses, and we hypothesise that the pattern of recruitment of leukocytes to tissues is critically dependent on the variable modulation of the endothelium by the local physicochemical microenvironment. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

U2 - 10.1016/j.febslet.2004.05.040

DO - 10.1016/j.febslet.2004.05.040

M3 - Article

C2 - 15225601

VL - 569

SP - 13

EP - 17

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1-3

ER -