The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins

Chris M. Bunce; Farhat L. Khanim

doi:10.1038/s41374-017-0012-5

The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins

Chris M. Bunce, Farhat L. Khanim

Biosciences

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

252 Downloads (Pure)

Abstract

Nucleoside diphosphate kinases (NDPKs/NDK/NME) are a multifunctional class of proteins conserved throughout evolution. Whilst many of the functions of NDPKs have been identified as intracellular, extracellular eukaryotic and prokaryotic NDPK proteins are also detected in multiple systems and have been implicated in both normal physiology and disease. This review provides an overview of where the field stands on our developing understanding of how NDPK proteins get out of cells, the physiological role of extracellular NDPKs, and how extracellular NDPKs may signal to cells. We will also discuss some of the unanswered questions, the 'known-unknowns' that particularly warrant further investigation.

Original language	English
Journal	Laboratory investigation
Early online date	16 Jan 2018
DOIs	https://doi.org/10.1038/s41374-017-0012-5
Publication status	E-pub ahead of print - 16 Jan 2018

Keywords

Journal Article
Review
extracellular signalling molecules
protein translocation

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Bunce_&_Farhat_The_known_knowns_Laboratory_Investigations_2018
Published in Laboratory Investigations on 16/01/2018 DOI: 10.1038/s41374-017-0012-5
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https://www.nature.com/articles/s41374-017-0012-5Licence: None: All rights reserved

Cite this

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AB - Nucleoside diphosphate kinases (NDPKs/NDK/NME) are a multifunctional class of proteins conserved throughout evolution. Whilst many of the functions of NDPKs have been identified as intracellular, extracellular eukaryotic and prokaryotic NDPK proteins are also detected in multiple systems and have been implicated in both normal physiology and disease. This review provides an overview of where the field stands on our developing understanding of how NDPK proteins get out of cells, the physiological role of extracellular NDPKs, and how extracellular NDPKs may signal to cells. We will also discuss some of the unanswered questions, the 'known-unknowns' that particularly warrant further investigation.

KW - Journal Article

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KW - extracellular signalling molecules

KW - protein translocation

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JO - Laboratory investigation

JF - Laboratory investigation

ER -

The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins

Abstract

Keywords

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