The killing action of fleroxacin upon Bacteroides fragilis

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Colleges, School and Institutes

Abstract

The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.

Details

Original languageEnglish
Pages (from-to)53-8
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume23
Issue number1
Publication statusPublished - Jan 1989

Keywords

  • Anti-Bacterial Agents, Bacteroides fragilis, Cell Cycle, Ciprofloxacin, Drug Resistance, Microbial, Fleroxacin, Microbial Sensitivity Tests