The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York:: The Manhattan Lupus Surveillance Program

Peter M. Izmirly; Isabella Wan; Sara Sahl; Jill P. Buyon; H. Michael Belmont; Jane E. Salmon; Anca Askanase; Joan M. Bathon; Laura Geraldino-pardilla; Yousaf Ali; Ellen M. Ginzler; Chaim Putterman; Caroline Gordon; Charles G. Helmick; Hilary Parton

doi:10.1002/art.40192

The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program

Peter M. Izmirly, Isabella Wan, Sara Sahl, Jill P. Buyon, H. Michael Belmont, Jane E. Salmon, Anca Askanase, Joan M. Bathon, Laura Geraldino-pardilla, Yousaf Ali, Ellen M. Ginzler, Chaim Putterman, Caroline Gordon, Charles G. Helmick, Hilary Parton

Inflammation and Ageing

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Abstract

Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of Systemic Lupus Erythematosus (SLE) in 2007 and incidence from 2007 to 2009 among Manhattan residents and characterize cases by race/ethnicity, including Asians and Hispanics for whom data are lacking.

Methods: We identified possible SLE cases from hospitals, rheumatologists, and administrative databases and defined cases using the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or a treating rheumatologist’s diagnosis. Rates among Manhattan residents were age-standardized, and capturerecapture (C-RC) analyses were conducted to assess case under-ascertainment.

Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years. Rates were approximately nine times higher in women than men for prevalence (107.4 vs. 12.5) and incidence (7.9 vs. 1.0). Compared with non-Hispanic (NH) white women (64.3), prevalence was higher among NH-black (210.9), Hispanic (138.3), and NH-Asian women (91.2). Incidence rates were higher among NH-black women (15.7) compared with NH-Asian (6.6), Hispanic (6.5), and NH-white women (6.5). C-RC adjustment increased prevalence and incidence rates (75.9 and 6.0). Alternate SLE definitions without C-RC adjustment found higher agestandardized prevalence and incidence rates (SLICC: 73.8 and 6.2; rheumatologist: 72.6 and 5.0) than the ACR definition, with similar patterns by sex and race/ethnicity.

Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and also provides estimates using the SLICC criteria.

Original language	English
Pages (from-to)	2006-2017
Number of pages	12
Journal	Arthritis & Rheumatology (Hoboken)
Volume	69
Issue number	10
Early online date	10 Sept 2017
DOIs	https://doi.org/10.1002/art.40192
Publication status	Published - Oct 2017

Keywords

Systemic
Lupus
Erythematosus
Systemic lupus erythematosus (SLE)
Epidemiology
Race/ethnicity

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Izmirly_et_al_The_incidence_and_prevalence_of_sle_Arthritis_&_Rheumatology_2017
This is the peer reviewed version of the following article: Izmirly, P. M., Wan, I., Sahl, S., Buyon, J. P., Belmont, H. M., Salmon, J. E., Askanase, A., Bathon, J. M., Geraldino-Pardilla, L., Ali, Y., Ginzler, E. M., Putterman, C., Gordon, C., Helmick, C. G. and Parton, H. (2017), The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program. Arthritis & Rheumatology, 69: 2006–2017., which has been published in final form at http://dx.doi.org/10.1002/art.40192. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Eligibility for repository: Checked on 13/4/2017
Accepted author manuscript, 818 KBLicence: Other (please specify with Rights Statement)

https://onlinelibrary.wiley.com/doi/full/10.1002/art.40192Licence: None: All rights reserved

Cite this

Izmirly, P. M., Wan, I., Sahl, S., Buyon, J. P., Belmont, H. M., Salmon, J. E., Askanase, A., Bathon, J. M., Geraldino-pardilla, L., Ali, Y., Ginzler, E. M., Putterman, C., Gordon, C., Helmick, C. G., & Parton, H. (2017). The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program. Arthritis & Rheumatology (Hoboken), 69(10), 2006-2017. https://doi.org/10.1002/art.40192

@article{51fbdb22494a4fb9b36117f908cf05a0,

title = "The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York:: The Manhattan Lupus Surveillance Program",

abstract = "Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of Systemic Lupus Erythematosus (SLE) in 2007 and incidence from 2007 to 2009 among Manhattan residents and characterize cases by race/ethnicity, including Asians and Hispanics for whom data are lacking.Methods: We identified possible SLE cases from hospitals, rheumatologists, and administrative databases and defined cases using the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or a treating rheumatologist{\textquoteright}s diagnosis. Rates among Manhattan residents were age-standardized, and capturerecapture (C-RC) analyses were conducted to assess case under-ascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years. Rates were approximately nine times higher in women than men for prevalence (107.4 vs. 12.5) and incidence (7.9 vs. 1.0). Compared with non-Hispanic (NH) white women (64.3), prevalence was higher among NH-black (210.9), Hispanic (138.3), and NH-Asian women (91.2). Incidence rates were higher among NH-black women (15.7) compared with NH-Asian (6.6), Hispanic (6.5), and NH-white women (6.5). C-RC adjustment increased prevalence and incidence rates (75.9 and 6.0). Alternate SLE definitions without C-RC adjustment found higher agestandardized prevalence and incidence rates (SLICC: 73.8 and 6.2; rheumatologist: 72.6 and 5.0) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and also provides estimates using the SLICC criteria.",

keywords = "Systemic , Lupus , Erythematosus, Systemic lupus erythematosus (SLE), Epidemiology , Race/ethnicity",

author = "Izmirly, {Peter M.} and Isabella Wan and Sara Sahl and Buyon, {Jill P.} and Belmont, {H. Michael} and Salmon, {Jane E.} and Anca Askanase and Bathon, {Joan M.} and Laura Geraldino-pardilla and Yousaf Ali and Ginzler, {Ellen M.} and Chaim Putterman and Caroline Gordon and Helmick, {Charles G.} and Hilary Parton",

year = "2017",

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doi = "10.1002/art.40192",

language = "English",

volume = "69",

pages = "2006--2017",

journal = "Arthritis & Rheumatology (Hoboken)",

issn = "2326-5191",

publisher = "Wiley",

number = "10",

}

Izmirly, PM, Wan, I, Sahl, S, Buyon, JP, Belmont, HM, Salmon, JE, Askanase, A, Bathon, JM, Geraldino-pardilla, L, Ali, Y, Ginzler, EM, Putterman, C, Gordon, C, Helmick, CG & Parton, H 2017, 'The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program', Arthritis & Rheumatology (Hoboken), vol. 69, no. 10, pp. 2006-2017. https://doi.org/10.1002/art.40192

TY - JOUR

T1 - The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York:

T2 - The Manhattan Lupus Surveillance Program

AU - Izmirly, Peter M.

AU - Wan, Isabella

AU - Sahl, Sara

AU - Buyon, Jill P.

AU - Belmont, H. Michael

AU - Salmon, Jane E.

AU - Askanase, Anca

AU - Bathon, Joan M.

AU - Geraldino-pardilla, Laura

AU - Ali, Yousaf

AU - Ginzler, Ellen M.

AU - Putterman, Chaim

AU - Gordon, Caroline

AU - Helmick, Charles G.

AU - Parton, Hilary

PY - 2017/10

Y1 - 2017/10

N2 - Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of Systemic Lupus Erythematosus (SLE) in 2007 and incidence from 2007 to 2009 among Manhattan residents and characterize cases by race/ethnicity, including Asians and Hispanics for whom data are lacking.Methods: We identified possible SLE cases from hospitals, rheumatologists, and administrative databases and defined cases using the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or a treating rheumatologist’s diagnosis. Rates among Manhattan residents were age-standardized, and capturerecapture (C-RC) analyses were conducted to assess case under-ascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years. Rates were approximately nine times higher in women than men for prevalence (107.4 vs. 12.5) and incidence (7.9 vs. 1.0). Compared with non-Hispanic (NH) white women (64.3), prevalence was higher among NH-black (210.9), Hispanic (138.3), and NH-Asian women (91.2). Incidence rates were higher among NH-black women (15.7) compared with NH-Asian (6.6), Hispanic (6.5), and NH-white women (6.5). C-RC adjustment increased prevalence and incidence rates (75.9 and 6.0). Alternate SLE definitions without C-RC adjustment found higher agestandardized prevalence and incidence rates (SLICC: 73.8 and 6.2; rheumatologist: 72.6 and 5.0) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and also provides estimates using the SLICC criteria.

AB - Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of Systemic Lupus Erythematosus (SLE) in 2007 and incidence from 2007 to 2009 among Manhattan residents and characterize cases by race/ethnicity, including Asians and Hispanics for whom data are lacking.Methods: We identified possible SLE cases from hospitals, rheumatologists, and administrative databases and defined cases using the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or a treating rheumatologist’s diagnosis. Rates among Manhattan residents were age-standardized, and capturerecapture (C-RC) analyses were conducted to assess case under-ascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years. Rates were approximately nine times higher in women than men for prevalence (107.4 vs. 12.5) and incidence (7.9 vs. 1.0). Compared with non-Hispanic (NH) white women (64.3), prevalence was higher among NH-black (210.9), Hispanic (138.3), and NH-Asian women (91.2). Incidence rates were higher among NH-black women (15.7) compared with NH-Asian (6.6), Hispanic (6.5), and NH-white women (6.5). C-RC adjustment increased prevalence and incidence rates (75.9 and 6.0). Alternate SLE definitions without C-RC adjustment found higher agestandardized prevalence and incidence rates (SLICC: 73.8 and 6.2; rheumatologist: 72.6 and 5.0) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and also provides estimates using the SLICC criteria.

KW - Systemic

KW - Lupus

KW - Erythematosus

KW - Systemic lupus erythematosus (SLE)

KW - Epidemiology

KW - Race/ethnicity

U2 - 10.1002/art.40192

DO - 10.1002/art.40192

M3 - Article

SN - 2326-5191

VL - 69

SP - 2006

EP - 2017

JO - Arthritis & Rheumatology (Hoboken)

JF - Arthritis & Rheumatology (Hoboken)

IS - 10

ER -

The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program

Abstract

Keywords

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