The incidence and prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program

Research output: Contribution to journalArticle

Authors

  • Peter M. Izmirly
  • Isabella Wan
  • Sara Sahl
  • Jill P. Buyon
  • H. Michael Belmont
  • Jane E. Salmon
  • Anca Askanase
  • Joan M. Bathon
  • Laura Geraldino-pardilla
  • Yousaf Ali
  • Ellen M. Ginzler
  • Chaim Putterman
  • Charles G. Helmick
  • Hilary Parton

Colleges, School and Institutes

External organisations

  • New York University School of Medicine
  • Hospital for Special Surgery, Weill Cornell Medical College; New York New York
  • Columbia University College of Physicians and Surgeons; New York New York
  • Icahn School of Medicine, Children's Heart Center, Mount Sinai Hospital, New York, New York, USA.
  • State University of New York Downstate College of Medicine; Brooklyn
  • Albert Einstein College of Medicine; Bronx New York
  • CDC; Atlanta Georgia
  • New York City Department of Health and Mental Hygiene; Long Island City New York

Abstract

Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of Systemic Lupus Erythematosus (SLE) in 2007 and incidence from 2007 to 2009 among Manhattan residents and characterize cases by race/ethnicity, including Asians and Hispanics for whom data are lacking.

Methods: We identified possible SLE cases from hospitals, rheumatologists, and administrative databases and defined cases using the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or a treating rheumatologist’s diagnosis. Rates among Manhattan residents were age-standardized, and capturerecapture (C-RC) analyses were conducted to assess case under-ascertainment.

Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years. Rates were approximately nine times higher in women than men for prevalence (107.4 vs. 12.5) and incidence (7.9 vs. 1.0). Compared with non-Hispanic (NH) white women (64.3), prevalence was higher among NH-black (210.9), Hispanic (138.3), and NH-Asian women (91.2). Incidence rates were higher among NH-black women (15.7) compared with NH-Asian (6.6), Hispanic (6.5), and NH-white women (6.5). C-RC adjustment increased prevalence and incidence rates (75.9 and 6.0). Alternate SLE definitions without C-RC adjustment found higher agestandardized prevalence and incidence rates (SLICC: 73.8 and 6.2; rheumatologist: 72.6 and 5.0) than the ACR definition, with similar patterns by sex and race/ethnicity.

Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and also provides estimates using the SLICC criteria.

Details

Original languageEnglish
Pages (from-to)2006-2017
Number of pages12
JournalArthritis & Rheumatology (Hoboken)
Volume69
Issue number10
Early online date10 Sep 2017
Publication statusPublished - Oct 2017

Keywords

  • Systemic , Lupus , Erythematosus, Systemic lupus erythematosus (SLE), Epidemiology , Race/ethnicity