The importance of p53 pathway genetics in inherited and somatic cancer genomes

Research output: Contribution to journalReview articlepeer-review

Authors

  • Giovanni Stracquadanio
  • Xuting Wang
  • Marsha D Wallace
  • Anna M Grawenda
  • Ping Zhang
  • Juliet Hewitt
  • Jorge Zeron-Medina
  • Francesc Castro-Giner
  • Ian P Tomlinson
  • Colin R Goding
  • Kamil J Cygan
  • William G Fairbrother
  • Laurent F Thomas
  • Pål Sætrom
  • Federica Gemignani
  • Stefano Landi
  • Benjamin Schuster-Böckler
  • Douglas A Bell

Colleges, School and Institutes

External organisations

  • Environmental Genomics Group, Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
  • Vall d'Hebron University Hospital, Oncology Department, Passeig de la Vall D'Hebron 119, 08035 Barcelona, Spain.
  • Norwegian University of Science and Technology
  • University of Pisa
  • University of Oxford
  • Brown University

Abstract

Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.

Details

Original languageEnglish
Pages (from-to)251-265
Number of pages15
JournalNature Reviews Cancer
Volume16
Issue number4
Early online date24 Mar 2016
Publication statusPublished - Apr 2016

Keywords

  • Genetic Predisposition to Disease/genetics, Genome, Human, Humans, Mutation, Neoplasms/genetics, Polymorphism, Single Nucleotide/genetics, Tumor Suppressor Protein p53/genetics