TY - JOUR
T1 - The importance of dynamic signalling for endocrine regulation and drug development
T2 - Relevance for glucocorticoid hormones
AU - Lightman, S.
AU - Terry, J.R.
PY - 2014/7
Y1 - 2014/7
N2 - Glucocorticoid hormones are heavily prescribed for several indications, including hormone replacement, anti-inflammatory effects, and antineoplastic effects. The pharmaceutical industry has put much effort into the development of novel potent glucocorticoid agonists, whereas there has been little enthusiasm for development of temporal aspects of glucocorticoid drugs. Glucocorticoids are normally secreted in a highly dynamic fashion, not only in the well known 24 h circadian rhythm, but also in an approximately hourly ultradian rhythm. These rhythms are crucial for normal gene regulation and for optimum cognitive function. In this Personal View, we discuss how understanding normal oscillatory patterns of glucocorticoid secretion could help investigators to develop novel glucocorticoid therapeutics that maximise the beneficial effect and diminish unwanted side-effects.
AB - Glucocorticoid hormones are heavily prescribed for several indications, including hormone replacement, anti-inflammatory effects, and antineoplastic effects. The pharmaceutical industry has put much effort into the development of novel potent glucocorticoid agonists, whereas there has been little enthusiasm for development of temporal aspects of glucocorticoid drugs. Glucocorticoids are normally secreted in a highly dynamic fashion, not only in the well known 24 h circadian rhythm, but also in an approximately hourly ultradian rhythm. These rhythms are crucial for normal gene regulation and for optimum cognitive function. In this Personal View, we discuss how understanding normal oscillatory patterns of glucocorticoid secretion could help investigators to develop novel glucocorticoid therapeutics that maximise the beneficial effect and diminish unwanted side-effects.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84903763145&partnerID=MN8TOARS
U2 - 10.1016/S2213-8587(13)70182-7
DO - 10.1016/S2213-8587(13)70182-7
M3 - Article
SN - 2213-8587
VL - 2
SP - 593
EP - 599
JO - The Lancet Diabetes and Endocrinology
JF - The Lancet Diabetes and Endocrinology
IS - 7
ER -