Abstract
Background: Liver transplantation is the only life-extending intervention for primary sclerosing cholangitis (PSC). Given the co-existence with colitis, patients may also require colectomy; a factor potentially conferring improved post-transplant outcomes.
Aim: Determine the impact of restorative surgery via ileal pouch anal anastomosis (IPAA) vs. retaining an end ileostomy on liver-related outcomes post-transplantation.
Methods: Graft survival was evaluated across a prospectively accrued transplant database, stratified according to colectomy status and type.
Results: Between 1990 and 2016, 240 individuals with PSC/colitis underwent transplantation (cumulative 1,870-patient-years until 1st graft loss or last follow-up date), of whom 75 also required colectomy. A heightened incidence of graft loss was observed for the IPAA group vs. those retaining an end ileostomy (2.8 vs. 0.4 per-100-patient-years, log-rank P=0.005), whereas rates between IPAA vs. no colectomy groups were not significantly different (2.8 vs. 1.7, P=0.1). Additionally, the ileostomy group experienced significantly lower graft loss rates vs. patients retaining an intact colon (P=0.044). The risks conferred by IPAA persisted when taking into account timings of colectomy as relates to liver transplantation via time-dependent Cox-regression analysis. Hepatic artery thrombosis and biliary strictures were the principal aetiologies of graft loss overall. Incidence rates for both were not significantly different between IPAA and no colectomy groups (P=0.092 and P=0.358); however, end ileostomy appeared protective (P=0.007 and 0.031, respectively).
Conclusion: In PSC liver transplantation, colectomy+IPAA is associated with a similar incidence rate of hepatic artery thrombosis, recurrent biliary strictures and re-transplantation compared to no colectomy; whereas colectomy+end ileostomy confers more favourable graft outcomes.
Aim: Determine the impact of restorative surgery via ileal pouch anal anastomosis (IPAA) vs. retaining an end ileostomy on liver-related outcomes post-transplantation.
Methods: Graft survival was evaluated across a prospectively accrued transplant database, stratified according to colectomy status and type.
Results: Between 1990 and 2016, 240 individuals with PSC/colitis underwent transplantation (cumulative 1,870-patient-years until 1st graft loss or last follow-up date), of whom 75 also required colectomy. A heightened incidence of graft loss was observed for the IPAA group vs. those retaining an end ileostomy (2.8 vs. 0.4 per-100-patient-years, log-rank P=0.005), whereas rates between IPAA vs. no colectomy groups were not significantly different (2.8 vs. 1.7, P=0.1). Additionally, the ileostomy group experienced significantly lower graft loss rates vs. patients retaining an intact colon (P=0.044). The risks conferred by IPAA persisted when taking into account timings of colectomy as relates to liver transplantation via time-dependent Cox-regression analysis. Hepatic artery thrombosis and biliary strictures were the principal aetiologies of graft loss overall. Incidence rates for both were not significantly different between IPAA and no colectomy groups (P=0.092 and P=0.358); however, end ileostomy appeared protective (P=0.007 and 0.031, respectively).
Conclusion: In PSC liver transplantation, colectomy+IPAA is associated with a similar incidence rate of hepatic artery thrombosis, recurrent biliary strictures and re-transplantation compared to no colectomy; whereas colectomy+end ileostomy confers more favourable graft outcomes.
Original language | English |
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Journal | Alimentary Pharmacology & Therapeutics |
Volume | 48 |
Issue number | 3 |
Early online date | 8 Jun 2018 |
DOIs | |
Publication status | Published - 11 Jul 2018 |
Bibliographical note
Article accepted for publication. Author Palak TrivediKeywords
- Ileorectal anastomosis
- Ischaemia reperfusion injury
- Primary sclerosing cholangitis
- Ulcerative colitis
- Inflammatory bowel disease
- colectomy
- pouchitis
- colonic resection
- hepatic artery thrombosis
- recurrent PSC