Projects per year
Abstract
The immune-mediated hepatobiliary diseases, primary biliary cirrhosis and primary sclerosing cholangitis are relatively rare, albeit and account for a significant amount of liver transplant activity and liver-related mortality globally. Precise disease mechanisms are yet to be described although a contributory role of genetic predisposition is firmly established. In addition to links with the major histocompatibility complex, a number of associations outside this region harbor additional loci which underscore the fundamental role of breaks in immune tolerance and mucosal immunogenicity in the pathogenesis of autoimmune biliary disease. We provide an overview of these key discoveries before discussing putative avenues of therapeutic exploitation based on existing findings.
Original language | English |
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Pages (from-to) | 15–31 |
Journal | Clinics in Liver Disease |
Volume | 20 |
Issue number | 1 |
Early online date | 20 Nov 2015 |
DOIs | |
Publication status | Published - Feb 2016 |
Keywords
- Autoimmunity
- Autoimmune liver disease
- Mucosal immunity
- Primary sclerosing cholangitis
- Primary biliary cirrhosis
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Dive into the research topics of 'The immunogenetics of autoimmune cholestasis'. Together they form a unique fingerprint.Projects
- 1 Finished
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The Therapeutic Potential of Vascular Adhesion Protein-1 in Primary Sclerosing Cholangitis
1/08/12 → 31/07/15
Project: Research