The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13

Simon Jones, G Watkins, N Le Good, S Roberts, C L Murphy, S M V Brockbank, M R C Needham, S J Read, P Newham

Research output: Contribution to journalArticlepeer-review

262 Citations (Scopus)

Abstract

To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their relevance to chondrocyte function.
Original languageEnglish
Pages (from-to)464-72
Number of pages9
JournalOsteoarthritis and Cartilage
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Tumor Necrosis Factor-alpha
  • MicroRNAs
  • Humans
  • Cartilage, Articular
  • Aged
  • Chondrocytes
  • Matrix Metalloproteinase 13
  • Computational Biology
  • Gene Expression Profiling
  • Osteoarthritis, Knee
  • Cells, Cultured
  • Inflammation Mediators
  • Gene Expression Regulation
  • Middle Aged
  • Signal Transduction

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