The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

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The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. / Loenarz, Christoph; Coleman, Mathew L; Boleininger, Anna; Schierwater, Bernd; Holland, Peter W H; Ratcliffe, Peter J; Schofield, Christopher J.

In: EMBO Reports, Vol. 12, No. 1, 01.2011, p. 63-70.

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Loenarz, Christoph ; Coleman, Mathew L ; Boleininger, Anna ; Schierwater, Bernd ; Holland, Peter W H ; Ratcliffe, Peter J ; Schofield, Christopher J. / The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. In: EMBO Reports. 2011 ; Vol. 12, No. 1. pp. 63-70.

Bibtex

@article{6f98fd755bbe4a5cb3e7584c46263ad1,
title = "The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens",
abstract = "The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.",
keywords = "Amino Acid Sequence, Animals, Hypoxia-Inducible Factor 1, Molecular Sequence Data, Oxygen, Phylogeny, Placozoa, Procollagen-Proline Dioxygenase, Transcriptional Activation, Von Hippel-Lindau Tumor Suppressor Protein",
author = "Christoph Loenarz and Coleman, {Mathew L} and Anna Boleininger and Bernd Schierwater and Holland, {Peter W H} and Ratcliffe, {Peter J} and Schofield, {Christopher J}",
year = "2011",
month = jan,
doi = "10.1038/embor.2010.170",
language = "English",
volume = "12",
pages = "63--70",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "EMBO Press",
number = "1",

}

RIS

TY - JOUR

T1 - The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

AU - Loenarz, Christoph

AU - Coleman, Mathew L

AU - Boleininger, Anna

AU - Schierwater, Bernd

AU - Holland, Peter W H

AU - Ratcliffe, Peter J

AU - Schofield, Christopher J

PY - 2011/1

Y1 - 2011/1

N2 - The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.

AB - The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.

KW - Amino Acid Sequence

KW - Animals

KW - Hypoxia-Inducible Factor 1

KW - Molecular Sequence Data

KW - Oxygen

KW - Phylogeny

KW - Placozoa

KW - Procollagen-Proline Dioxygenase

KW - Transcriptional Activation

KW - Von Hippel-Lindau Tumor Suppressor Protein

U2 - 10.1038/embor.2010.170

DO - 10.1038/embor.2010.170

M3 - Article

C2 - 21109780

VL - 12

SP - 63

EP - 70

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

IS - 1

ER -