The highs and lows of beta activity in cortico-basal ganglia loops

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The highs and lows of beta activity in cortico-basal ganglia loops. / Brittain, John-stuart; Sharott, Andrew; Brown, Peter.

In: European Journal of Neuroscience, Vol. 39, No. 11, 01.06.2014, p. 1951-1959.

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Brittain, John-stuart ; Sharott, Andrew ; Brown, Peter. / The highs and lows of beta activity in cortico-basal ganglia loops. In: European Journal of Neuroscience. 2014 ; Vol. 39, No. 11. pp. 1951-1959.

Bibtex

@article{ac3b2df60be84820be906873b28f136d,
title = "The highs and lows of beta activity in cortico-basal ganglia loops",
abstract = "Oscillatory activity in the beta (13–30 Hz) frequency band is widespread in cortico‐basal ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the hypothesis that the degree of synchronization in this frequency band is a critical factor in gating computation across a population of neurons, with increases in beta band synchrony entailing a loss of information‐coding space and hence computational capacity. Task and context drive this dynamic gating, so that for each state there will be an optimal level of network synchrony, and levels lower or higher than this will impair behavioural performance. Thus, both the pathological exaggeration of synchrony, as observed in PD, and the ability of interventions like deep brain stimulation (DBS) to excessively suppress synchrony can potentially lead to impairments in behavioural performance. Indeed, under physiological conditions, the manipulation of computational capacity by beta activity may itself present a mechanism of action selection and maintenance.",
keywords = "basal ganglia, beta activity, cortical, nformation transfer, Parkinson{\textquoteright}s disease, synchronization",
author = "John-stuart Brittain and Andrew Sharott and Peter Brown",
year = "2014",
month = jun,
day = "1",
doi = "10.1111/ejn.12574",
language = "English",
volume = "39",
pages = "1951--1959",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley",
number = "11",

}

RIS

TY - JOUR

T1 - The highs and lows of beta activity in cortico-basal ganglia loops

AU - Brittain, John-stuart

AU - Sharott, Andrew

AU - Brown, Peter

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Oscillatory activity in the beta (13–30 Hz) frequency band is widespread in cortico‐basal ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the hypothesis that the degree of synchronization in this frequency band is a critical factor in gating computation across a population of neurons, with increases in beta band synchrony entailing a loss of information‐coding space and hence computational capacity. Task and context drive this dynamic gating, so that for each state there will be an optimal level of network synchrony, and levels lower or higher than this will impair behavioural performance. Thus, both the pathological exaggeration of synchrony, as observed in PD, and the ability of interventions like deep brain stimulation (DBS) to excessively suppress synchrony can potentially lead to impairments in behavioural performance. Indeed, under physiological conditions, the manipulation of computational capacity by beta activity may itself present a mechanism of action selection and maintenance.

AB - Oscillatory activity in the beta (13–30 Hz) frequency band is widespread in cortico‐basal ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the hypothesis that the degree of synchronization in this frequency band is a critical factor in gating computation across a population of neurons, with increases in beta band synchrony entailing a loss of information‐coding space and hence computational capacity. Task and context drive this dynamic gating, so that for each state there will be an optimal level of network synchrony, and levels lower or higher than this will impair behavioural performance. Thus, both the pathological exaggeration of synchrony, as observed in PD, and the ability of interventions like deep brain stimulation (DBS) to excessively suppress synchrony can potentially lead to impairments in behavioural performance. Indeed, under physiological conditions, the manipulation of computational capacity by beta activity may itself present a mechanism of action selection and maintenance.

KW - basal ganglia

KW - beta activity

KW - cortical

KW - nformation transfer

KW - Parkinson’s disease

KW - synchronization

U2 - 10.1111/ejn.12574

DO - 10.1111/ejn.12574

M3 - Article

VL - 39

SP - 1951

EP - 1959

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 11

ER -