The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease

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The hidden cost of modern medical interventions : how medical advances have shaped the prevalence of human fungal disease. / Clark, Callum; Drummond, Rebecca.

In: Pathogens, Vol. 8, No. 2, 45, 04.04.2019, p. 1-11.

Research output: Contribution to journalReview articlepeer-review

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@article{9998325fd6df4e4f8f92ab563df91776,
title = "The hidden cost of modern medical interventions: how medical advances have shaped the prevalence of human fungal disease",
abstract = "Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence of opportunistic infections has also been observed. These include several fungal infections, which present a particular clinical challenge due to the lack of fungal vaccines, limited diagnostics and increasing antifungal drug resistance. This mini-review outlines how modern-day clinical practices have shaped the recent increase in fungal diseases observed in the last few decades. We discuss new research that has implicated the use of immune-modulating drugs in the enhanced susceptibility of vulnerable patients to life-threatening fungal infections.",
keywords = "fungi, antibiotics, corticosteroids, ibrutinib, Candida, Aspergillus, macrophage",
author = "Callum Clark and Rebecca Drummond",
year = "2019",
month = apr,
day = "4",
doi = "10.3390/pathogens8020045",
language = "English",
volume = "8",
pages = "1--11",
journal = "Pathogens",
issn = "2076-0817",
publisher = "MDPI",
number = "2",

}

RIS

TY - JOUR

T1 - The hidden cost of modern medical interventions

T2 - how medical advances have shaped the prevalence of human fungal disease

AU - Clark, Callum

AU - Drummond, Rebecca

PY - 2019/4/4

Y1 - 2019/4/4

N2 - Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence of opportunistic infections has also been observed. These include several fungal infections, which present a particular clinical challenge due to the lack of fungal vaccines, limited diagnostics and increasing antifungal drug resistance. This mini-review outlines how modern-day clinical practices have shaped the recent increase in fungal diseases observed in the last few decades. We discuss new research that has implicated the use of immune-modulating drugs in the enhanced susceptibility of vulnerable patients to life-threatening fungal infections.

AB - Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence of opportunistic infections has also been observed. These include several fungal infections, which present a particular clinical challenge due to the lack of fungal vaccines, limited diagnostics and increasing antifungal drug resistance. This mini-review outlines how modern-day clinical practices have shaped the recent increase in fungal diseases observed in the last few decades. We discuss new research that has implicated the use of immune-modulating drugs in the enhanced susceptibility of vulnerable patients to life-threatening fungal infections.

KW - fungi

KW - antibiotics

KW - corticosteroids

KW - ibrutinib

KW - Candida

KW - Aspergillus

KW - macrophage

UR - https://www.ncbi.nlm.nih.gov/pubmed/30987351

U2 - 10.3390/pathogens8020045

DO - 10.3390/pathogens8020045

M3 - Review article

VL - 8

SP - 1

EP - 11

JO - Pathogens

JF - Pathogens

SN - 2076-0817

IS - 2

M1 - 45

ER -