The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Davor Pavlović; David C A Neville; Olivier Argaud; Baruch Blumberg; Raymond A Dwek; Wolfgang B Fischer; Nicole Zitzmann

doi:10.1073/pnas.1031527100

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Davor Pavlović, David C A Neville, Olivier Argaud, Baruch Blumberg, Raymond A Dwek, Wolfgang B Fischer, Nicole Zitzmann

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

298 Citations (Scopus)

Abstract

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

Original language	English
Pages (from-to)	6104-8
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	10
DOIs	https://doi.org/10.1073/pnas.1031527100
Publication status	Published - 13 May 2003

Keywords

Amino Acid Sequence
Carbohydrates
Hepacivirus
Imines
Ion Channels
Lipid Bilayers
Membrane Potentials
Molecular Sequence Data
Peptides
Viral Proteins
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.1031527100

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title = "The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives",

abstract = "We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.",

keywords = "Amino Acid Sequence, Carbohydrates, Hepacivirus, Imines, Ion Channels, Lipid Bilayers, Membrane Potentials, Molecular Sequence Data, Peptides, Viral Proteins, Journal Article, Research Support, Non-U.S. Gov't",

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year = "2003",

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doi = "10.1073/pnas.1031527100",

language = "English",

volume = "100",

pages = "6104--8",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "10",

}

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. / Pavlović, Davor; Neville, David C A; Argaud, Olivier et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 10, 13.05.2003, p. 6104-8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

AU - Pavlović, Davor

AU - Neville, David C A

AU - Argaud, Olivier

AU - Blumberg, Baruch

AU - Dwek, Raymond A

AU - Fischer, Wolfgang B

AU - Zitzmann, Nicole

PY - 2003/5/13

Y1 - 2003/5/13

N2 - We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

AB - We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

KW - Amino Acid Sequence

KW - Carbohydrates

KW - Hepacivirus

KW - Imines

KW - Ion Channels

KW - Lipid Bilayers

KW - Membrane Potentials

KW - Molecular Sequence Data

KW - Peptides

KW - Viral Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1073/pnas.1031527100

DO - 10.1073/pnas.1031527100

M3 - Article

C2 - 12719519

SN - 0027-8424

VL - 100

SP - 6104

EP - 6108

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 10

ER -

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Abstract

Keywords

UN SDGs

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