The giant titin: how to evaluate its role in cardiomyopathies

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The giant titin : how to evaluate its role in cardiomyopathies. / Azad, Amar; Poloni, Giulia; Sontayananon, Naeramit; Jiang, He; Gehmlich, Katja.

In: Journal of Muscle Research and Cell Motility, Vol. 40, No. 2, 06.2019, p. 159-167.

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Azad, Amar ; Poloni, Giulia ; Sontayananon, Naeramit ; Jiang, He ; Gehmlich, Katja. / The giant titin : how to evaluate its role in cardiomyopathies. In: Journal of Muscle Research and Cell Motility. 2019 ; Vol. 40, No. 2. pp. 159-167.

Bibtex

@article{a5daa5074f7d4d90b47ef7f0fc56bf61,
title = "The giant titin: how to evaluate its role in cardiomyopathies",
abstract = "Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies.",
keywords = "Animal models, CRISPR/Cas9, Cardiomyopathy, Genome-engineering, Induced pluripotent stem cell derived cardiomyocytes, Titin",
author = "Amar Azad and Giulia Poloni and Naeramit Sontayananon and He Jiang and Katja Gehmlich",
year = "2019",
month = jun,
doi = "10.1007/s10974-019-09518-w",
language = "English",
volume = "40",
pages = "159--167",
journal = "Journal of Muscle Research and Cell Motility",
issn = "0142-4319",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - The giant titin

T2 - how to evaluate its role in cardiomyopathies

AU - Azad, Amar

AU - Poloni, Giulia

AU - Sontayananon, Naeramit

AU - Jiang, He

AU - Gehmlich, Katja

PY - 2019/6

Y1 - 2019/6

N2 - Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies.

AB - Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies.

KW - Animal models

KW - CRISPR/Cas9

KW - Cardiomyopathy

KW - Genome-engineering

KW - Induced pluripotent stem cell derived cardiomyocytes

KW - Titin

UR - http://www.scopus.com/inward/record.url?scp=85066600746&partnerID=8YFLogxK

U2 - 10.1007/s10974-019-09518-w

DO - 10.1007/s10974-019-09518-w

M3 - Article

C2 - 31147888

VL - 40

SP - 159

EP - 167

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

SN - 0142-4319

IS - 2

ER -