The genetics of chronic obstructive pulmonary disease

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

Abstract

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation.

Details

Original languageEnglish
Pages (from-to)130
Number of pages1
JournalRespiratory research
Volume7
Publication statusPublished - 20 Oct 2006