The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma

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The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma. / Contino, Gianmarco; Vaughan, Thomas L; Whiteman, David; Fitzgerald, Rebecca C.

In: Gastroenterology, Vol. 153, No. 3, 09.2017, p. 657-673.e1.

Research output: Contribution to journalReview articlepeer-review

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Contino, Gianmarco ; Vaughan, Thomas L ; Whiteman, David ; Fitzgerald, Rebecca C. / The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma. In: Gastroenterology. 2017 ; Vol. 153, No. 3. pp. 657-673.e1.

Bibtex

@article{c3b501ea2625471589a5cf5e45848aee,
title = "The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma",
abstract = "We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.",
keywords = "Adenocarcinoma/diagnosis, Barrett Esophagus/genetics, Carcinogenesis/genetics, DNA Copy Number Variations, Esophageal Neoplasms/diagnosis, Genome-Wide Association Study, Germ-Line Mutation, Humans, Mutation",
author = "Gianmarco Contino and Vaughan, {Thomas L} and David Whiteman and Fitzgerald, {Rebecca C}",
note = "Copyright {\textcopyright} 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = sep,
doi = "10.1053/j.gastro.2017.07.007",
language = "English",
volume = "153",
pages = "657--673.e1",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma

AU - Contino, Gianmarco

AU - Vaughan, Thomas L

AU - Whiteman, David

AU - Fitzgerald, Rebecca C

N1 - Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.

AB - We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.

KW - Adenocarcinoma/diagnosis

KW - Barrett Esophagus/genetics

KW - Carcinogenesis/genetics

KW - DNA Copy Number Variations

KW - Esophageal Neoplasms/diagnosis

KW - Genome-Wide Association Study

KW - Germ-Line Mutation

KW - Humans

KW - Mutation

U2 - 10.1053/j.gastro.2017.07.007

DO - 10.1053/j.gastro.2017.07.007

M3 - Review article

C2 - 28716721

VL - 153

SP - 657-673.e1

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -