The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.
|Number of pages||18|
|Early online date||14 Jul 2017|
|Publication status||Published - Sep 2017|
- Adenocarcinoma/diagnosis, Barrett Esophagus/genetics, Carcinogenesis/genetics, DNA Copy Number Variations, Esophageal Neoplasms/diagnosis, Genome-Wide Association Study, Germ-Line Mutation, Humans, Mutation