The epidemiology of aggresssive pituitary tumors (and its challenges)

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

External organisations

  • Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Nederlands

Abstract

Pituitary tumors are not rare if prevalence rates from autopsy or radiological series are considered; approximately 0.5% of all pituitary adenomas will come to medical attention. Less than 0.1% of these pituitary adenomas will become malignant, and probably around 0.5% of all detected adenomas will display an aggressive course. However, the exact incidence of both aggressive pituitary adenomas and pituitary carcinomas is unknown, as most data come from series with selected patients, such as surgically treated patients, which is likely not a reflection of all patients with a pituitary adenoma. An aggressive pituitary adenoma is not well-defined; even though an overarching definition, capturing both immunohistochemical and clinical characteristics is probably not waterproof, adoption of a widely accepted definition will be very helpful to harmonize research and establish more reliable epidemiological data.

Details

Original languageEnglish
JournalReviews in endocrine & metabolic disorders
Publication statusPublished - 2 May 2020

Keywords

  • Aggressive pituitary adenoma, Carcinoma, Epidemiology, Incidence