The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

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The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism. / Fletcher, Rachel S; Lavery, Gareth G.

In: Journal of Molecular Endocrinology, Vol. 61, No. 3, 01.10.2018, p. R107-R121.

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@article{6015f42abe5f4439a8c7b14c20f0e902,
title = "The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism",
abstract = "The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+ availability such that strategies to intervene in the clinical setting are able to be fully realised. This review discusses the importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the recently identified nicotinamide riboside kinase pathway at both a tissue-specific and systemic level.",
keywords = "NAD+, metabolism, nicotinamide riboside, energy",
author = "Fletcher, {Rachel S} and Lavery, {Gareth G}",
note = "{\textcopyright} 2018 The authors",
year = "2018",
month = oct,
day = "1",
doi = "10.1530/JME-18-0085",
language = "English",
volume = "61",
pages = "R107--R121",
journal = "Journal of Molecular Endocrinology",
issn = "0952-5041",
publisher = "BioScientifica",
number = "3",

}

RIS

TY - JOUR

T1 - The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

AU - Fletcher, Rachel S

AU - Lavery, Gareth G

N1 - © 2018 The authors

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+ availability such that strategies to intervene in the clinical setting are able to be fully realised. This review discusses the importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the recently identified nicotinamide riboside kinase pathway at both a tissue-specific and systemic level.

AB - The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+ availability such that strategies to intervene in the clinical setting are able to be fully realised. This review discusses the importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the recently identified nicotinamide riboside kinase pathway at both a tissue-specific and systemic level.

KW - NAD+

KW - metabolism

KW - nicotinamide riboside

KW - energy

U2 - 10.1530/JME-18-0085

DO - 10.1530/JME-18-0085

M3 - Article

C2 - 30307159

VL - 61

SP - R107-R121

JO - Journal of Molecular Endocrinology

JF - Journal of Molecular Endocrinology

SN - 0952-5041

IS - 3

ER -