TY - JOUR
T1 - The effects of exercise on cardiovascular disease risk factors and cardiovascular physiology in rheumatoid arthritis
AU - Metsios, George S
AU - Moe, R.H
AU - van der Esch, M
AU - Veldhuijzen van Zanten, Joachimina
AU - Fenton, Sally
AU - Koutedakis, Y
AU - Vitalis, Panos
AU - Kennedy, N
AU - Brodin, N
AU - Bostrom, C
AU - Swinnen, T.W
AU - Tzika, K
AU - Niedermann, K
AU - Nikiphorou, E
AU - Fragoulis, G.E.
AU - Vlieland, T.P.V.M.
AU - Van den Ende, C.H.M.
AU - Kitas, George
AU - IMPACT-RMD Consortium
PY - 2020/3
Y1 - 2020/3
N2 - Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) can significantly improve patient-reported and clinical index-assessed outcomes in RA. In addition to this, engagement in exercise programmes improves, in a dose-dependent manner, the risk of developing CVD as well as CVD symptoms and outcomes. The present narrative review uses evidence from systematic reviews and meta-analyses as well as controlled trials, to synthesize the current state-of-the-art on the potential effects of aerobic and resistance exercise on CVD risk factors as well as on cardiac and vascular function and structure in people with RA. Where there is a lack of evidence in RA to explain potential mechanisms, relevant studies from the general population are also discussed and linked to RA.
AB - Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) can significantly improve patient-reported and clinical index-assessed outcomes in RA. In addition to this, engagement in exercise programmes improves, in a dose-dependent manner, the risk of developing CVD as well as CVD symptoms and outcomes. The present narrative review uses evidence from systematic reviews and meta-analyses as well as controlled trials, to synthesize the current state-of-the-art on the potential effects of aerobic and resistance exercise on CVD risk factors as well as on cardiac and vascular function and structure in people with RA. Where there is a lack of evidence in RA to explain potential mechanisms, relevant studies from the general population are also discussed and linked to RA.
KW - Autoimmune disease
KW - Cardiovascular disease
KW - Exercise
KW - Inflammation
KW - Non-communicable disease
KW - Physical activity
KW - Rehabilitation
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85076097850&partnerID=8YFLogxK
U2 - 10.1007/s00296-019-04483-6
DO - 10.1007/s00296-019-04483-6
M3 - Article
SN - 0172-8172
VL - 40
SP - 347
EP - 357
JO - Rheumatology International
JF - Rheumatology International
IS - 3
ER -
