The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

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Colleges, School and Institutes


Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.


Original languageEnglish
Pages (from-to)205-10
Number of pages6
JournalJournal of Medical Microbiology
Issue number3
Publication statusPublished - May 1987


  • Alkaline Phosphatase, Animals, Bacterial Proteins, Bacterial Toxins, Cell Membrane Permeability, Cells, Cultured, Clostridium, Enterotoxins, In Vitro Techniques, Intestines, Protein Biosynthesis, Rabbits