The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

Abstract

Clostridium difficile crude toxins and purified toxin A had similar effects on stripped rabbit ileal mucosa in Ussing chambers. Both toxin preparations caused secretion of sodium and chloride ions by increasing serosa to mucosa (s----m) fluxes. Transmural potential difference and resistance decreased after toxin treatment. Onset of changes in electrical measurements and ion fluxes coincided with onset of histological changes. The response to theophylline was greatly reduced in toxin-treated tissue compared with control tissue.

Details

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalJournal of Medical Microbiology
Volume23
Issue number3
Publication statusPublished - May 1987

Keywords

  • Animals, Bacterial Proteins, Bacterial Toxins, Chlorides, Clostridium, Enterotoxins, Ileum, In Vitro Techniques, Intestinal Mucosa, Male, Rabbits, Sodium, Theophylline