The effects of a prebiotic supplementation on reading and cognitive performance in elementary school children: a randomised placebo-controlled study

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The effects of a prebiotic supplementation on reading and cognitive performance in elementary school children: a randomised placebo-controlled study . / Capitao, Liliana; Baiao, Rita; Baek, Hee; Kappelmann, Nils; Sharman, Rachel; Harvey, Christopher J ; Montgomery, Paul; Burnet, Philip.

In: Biological Psychiatry, Vol. 85, No. 10, S53, 15.05.2019, p. s316-s317.

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Capitao, Liliana ; Baiao, Rita ; Baek, Hee ; Kappelmann, Nils ; Sharman, Rachel ; Harvey, Christopher J ; Montgomery, Paul ; Burnet, Philip. / The effects of a prebiotic supplementation on reading and cognitive performance in elementary school children: a randomised placebo-controlled study . In: Biological Psychiatry. 2019 ; Vol. 85, No. 10. pp. s316-s317.

Bibtex

@article{71e9f08a297c43d1abaafc0a20feaa60,
title = "The effects of a prebiotic supplementation on reading and cognitive performance in elementary school children:: a randomised placebo-controlled study ",
abstract = "Background Childhood is a developmental period characterised by substantial changes in cognitive abilities. There has been an emerging interest in how manipulating gut microbiota can enrich the developing brain with improved emotional and cognitive functions, but to date this has not been tested in children. In this study, we investigate whether the daily intake of a prebiotic supplement (galacto-oliogosaccharides, Bimuno{\textregistered}, B-GOS) by children influenced their reading and cognitive abilities.Methods35 children aged 7-9 with below-average reading scores received a 12-week treatment with the prebiotic or a matched placebo in this randomised, double-blind, between-subjects, placebo-controlled study. Reading and working memory (British Ability Scales) and broader cognition (CogTrackTMSystem) were assessed. As a secondary aim, the effects of the prebiotic on sleep (actigraphy and questionnaire), behaviour, mood, anxiety and cortisol (saliva samples) were also evaluated using mixed-design ANOVAs.ResultsDaily intake of the B-GOS prebiotic did not affect reading (p=.536), cognition (p>.148), or any of the secondary measures assessed, compared to placebo. Both treatment groups improved over time in reading and memory retrieval speed. In addition, both groups displayed a decline in actual sleep time and immobile minutes.ConclusionsIn this sample, the prebiotic did not influence any of the outcome measures. It is possible that at this age-range, behaviour, immunity and diets are erratic and could potentially confound the effects of the supplement; or that the influence of gut bacteria on the brain is not fully established in early-life. Future studies should explore the relationship between the gut microbiome and cognition across development.",
author = "Liliana Capitao and Rita Baiao and Hee Baek and Nils Kappelmann and Rachel Sharman and Harvey, {Christopher J} and Paul Montgomery and Philip Burnet",
year = "2019",
month = may,
day = "15",
doi = "10.1016/j.biopsych.2019.03.804",
language = "English",
volume = "85",
pages = "s316--s317",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - The effects of a prebiotic supplementation on reading and cognitive performance in elementary school children:

T2 - a randomised placebo-controlled study

AU - Capitao, Liliana

AU - Baiao, Rita

AU - Baek, Hee

AU - Kappelmann, Nils

AU - Sharman, Rachel

AU - Harvey, Christopher J

AU - Montgomery, Paul

AU - Burnet, Philip

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Background Childhood is a developmental period characterised by substantial changes in cognitive abilities. There has been an emerging interest in how manipulating gut microbiota can enrich the developing brain with improved emotional and cognitive functions, but to date this has not been tested in children. In this study, we investigate whether the daily intake of a prebiotic supplement (galacto-oliogosaccharides, Bimuno®, B-GOS) by children influenced their reading and cognitive abilities.Methods35 children aged 7-9 with below-average reading scores received a 12-week treatment with the prebiotic or a matched placebo in this randomised, double-blind, between-subjects, placebo-controlled study. Reading and working memory (British Ability Scales) and broader cognition (CogTrackTMSystem) were assessed. As a secondary aim, the effects of the prebiotic on sleep (actigraphy and questionnaire), behaviour, mood, anxiety and cortisol (saliva samples) were also evaluated using mixed-design ANOVAs.ResultsDaily intake of the B-GOS prebiotic did not affect reading (p=.536), cognition (p>.148), or any of the secondary measures assessed, compared to placebo. Both treatment groups improved over time in reading and memory retrieval speed. In addition, both groups displayed a decline in actual sleep time and immobile minutes.ConclusionsIn this sample, the prebiotic did not influence any of the outcome measures. It is possible that at this age-range, behaviour, immunity and diets are erratic and could potentially confound the effects of the supplement; or that the influence of gut bacteria on the brain is not fully established in early-life. Future studies should explore the relationship between the gut microbiome and cognition across development.

AB - Background Childhood is a developmental period characterised by substantial changes in cognitive abilities. There has been an emerging interest in how manipulating gut microbiota can enrich the developing brain with improved emotional and cognitive functions, but to date this has not been tested in children. In this study, we investigate whether the daily intake of a prebiotic supplement (galacto-oliogosaccharides, Bimuno®, B-GOS) by children influenced their reading and cognitive abilities.Methods35 children aged 7-9 with below-average reading scores received a 12-week treatment with the prebiotic or a matched placebo in this randomised, double-blind, between-subjects, placebo-controlled study. Reading and working memory (British Ability Scales) and broader cognition (CogTrackTMSystem) were assessed. As a secondary aim, the effects of the prebiotic on sleep (actigraphy and questionnaire), behaviour, mood, anxiety and cortisol (saliva samples) were also evaluated using mixed-design ANOVAs.ResultsDaily intake of the B-GOS prebiotic did not affect reading (p=.536), cognition (p>.148), or any of the secondary measures assessed, compared to placebo. Both treatment groups improved over time in reading and memory retrieval speed. In addition, both groups displayed a decline in actual sleep time and immobile minutes.ConclusionsIn this sample, the prebiotic did not influence any of the outcome measures. It is possible that at this age-range, behaviour, immunity and diets are erratic and could potentially confound the effects of the supplement; or that the influence of gut bacteria on the brain is not fully established in early-life. Future studies should explore the relationship between the gut microbiome and cognition across development.

U2 - 10.1016/j.biopsych.2019.03.804

DO - 10.1016/j.biopsych.2019.03.804

M3 - Article

VL - 85

SP - s316-s317

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 10

M1 - S53

ER -