The effectiveness of antipsychotic medication in the management of behaviour problems in adults with intellectual disabilities

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@article{0e1094b8f4394ffab5de4f845f23dce8,
title = "The effectiveness of antipsychotic medication in the management of behaviour problems in adults with intellectual disabilities",
abstract = "Background Psychopharmacological intervention in the management of behaviour problems in adults with intellectual disabilities (ID) has become a common treatment strategy. This has become a cause for concern, given that the evidence for its effectiveness is uncertain and most drugs are not licensed for this use. Methods A comprehensive systematic review of empirical research on the effectiveness of antipsychotic medication was conducted. Electronic and manual searches of literature were conducted. Stringent scientific methodology determined those primary trials that were worthy of inclusion. Results This review revealed one randomized controlled trial (RCT), one controlled, four uncontrolled prospective and three retrospective case series studies in adults. Additionally, two studies in both adults and children - one crossover RCT and one prospective controlled trial - were found. Conclusions Presently, there is RCT-based evidence for risperidone to be effective in both adults and children; however, this treatment carries a certain amount of risk associated with adverse effects. There is also evidence to support the use of other antipsychotics, primarily atypicals, but the evidence is based on noncontrolled case studies. There is currently not enough evidence available to recommend specific medication for specific behaviour problems. Before prescribing medication, clinicians should carry out a thorough assessment of behaviour, including its causes and consequences, and draw up a formulation providing the rationale for the prescribed intervention after considering all medication- and nonmedication-based management options.",
author = "Saumitra Deb and Sundip Sohanpal and Rivashni Soni and L Lenotre and Gemma Unwin",
year = "2007",
month = oct,
day = "1",
doi = "10.1111/j.1365-2788.2007.00950.x",
language = "English",
volume = "51",
pages = "766--77",
journal = "Journal of Intellectual Disability Research",
issn = "0964-2633",
publisher = "Wiley",
number = "10",

}

RIS

TY - JOUR

T1 - The effectiveness of antipsychotic medication in the management of behaviour problems in adults with intellectual disabilities

AU - Deb, Saumitra

AU - Sohanpal, Sundip

AU - Soni, Rivashni

AU - Lenotre, L

AU - Unwin, Gemma

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background Psychopharmacological intervention in the management of behaviour problems in adults with intellectual disabilities (ID) has become a common treatment strategy. This has become a cause for concern, given that the evidence for its effectiveness is uncertain and most drugs are not licensed for this use. Methods A comprehensive systematic review of empirical research on the effectiveness of antipsychotic medication was conducted. Electronic and manual searches of literature were conducted. Stringent scientific methodology determined those primary trials that were worthy of inclusion. Results This review revealed one randomized controlled trial (RCT), one controlled, four uncontrolled prospective and three retrospective case series studies in adults. Additionally, two studies in both adults and children - one crossover RCT and one prospective controlled trial - were found. Conclusions Presently, there is RCT-based evidence for risperidone to be effective in both adults and children; however, this treatment carries a certain amount of risk associated with adverse effects. There is also evidence to support the use of other antipsychotics, primarily atypicals, but the evidence is based on noncontrolled case studies. There is currently not enough evidence available to recommend specific medication for specific behaviour problems. Before prescribing medication, clinicians should carry out a thorough assessment of behaviour, including its causes and consequences, and draw up a formulation providing the rationale for the prescribed intervention after considering all medication- and nonmedication-based management options.

AB - Background Psychopharmacological intervention in the management of behaviour problems in adults with intellectual disabilities (ID) has become a common treatment strategy. This has become a cause for concern, given that the evidence for its effectiveness is uncertain and most drugs are not licensed for this use. Methods A comprehensive systematic review of empirical research on the effectiveness of antipsychotic medication was conducted. Electronic and manual searches of literature were conducted. Stringent scientific methodology determined those primary trials that were worthy of inclusion. Results This review revealed one randomized controlled trial (RCT), one controlled, four uncontrolled prospective and three retrospective case series studies in adults. Additionally, two studies in both adults and children - one crossover RCT and one prospective controlled trial - were found. Conclusions Presently, there is RCT-based evidence for risperidone to be effective in both adults and children; however, this treatment carries a certain amount of risk associated with adverse effects. There is also evidence to support the use of other antipsychotics, primarily atypicals, but the evidence is based on noncontrolled case studies. There is currently not enough evidence available to recommend specific medication for specific behaviour problems. Before prescribing medication, clinicians should carry out a thorough assessment of behaviour, including its causes and consequences, and draw up a formulation providing the rationale for the prescribed intervention after considering all medication- and nonmedication-based management options.

U2 - 10.1111/j.1365-2788.2007.00950.x

DO - 10.1111/j.1365-2788.2007.00950.x

M3 - Article

C2 - 17803495

VL - 51

SP - 766

EP - 777

JO - Journal of Intellectual Disability Research

JF - Journal of Intellectual Disability Research

SN - 0964-2633

IS - 10

ER -