The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours: protocol for a systematic review

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The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours : protocol for a systematic review. / Main, Caroline; Dandapani, Madhumita; Pritchard, Mark; Dodds, Rachel; Stevens, Simon P; Thorp, Nicky; Taylor, Roger E; Wheatley, Keith; Pizer, Barry; Morrall, Matthew; Phillips, Robert; English, Martin; Kearns, Pamela R; Wilne, Sophie; Wilson, Jayne S.

In: Systematic Reviews, Vol. 5, No. 1, 124, 27.07.2016.

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Main, Caroline ; Dandapani, Madhumita ; Pritchard, Mark ; Dodds, Rachel ; Stevens, Simon P ; Thorp, Nicky ; Taylor, Roger E ; Wheatley, Keith ; Pizer, Barry ; Morrall, Matthew ; Phillips, Robert ; English, Martin ; Kearns, Pamela R ; Wilne, Sophie ; Wilson, Jayne S. / The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours : protocol for a systematic review. In: Systematic Reviews. 2016 ; Vol. 5, No. 1.

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@article{4784ae1c3fdb4970b1723029b18071b6,
title = "The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours: protocol for a systematic review",
abstract = "BACKGROUND: The aim of this study is to use a systematic review framework to identify and synthesise the evidence on the use of proton beam therapy (PBT) for the treatment of children with CNS tumours and where possible compare this to the use of photon radiotherapy (RT).METHODS: Standard systematic review methods aimed at minimising bias will be employed for study identification, selection and data extraction. Twelve electronic databases have been searched, and further citation, hand searching and reference checking will be employed. Studies assessing the effects of PBT used either alone or as part of a multimodality treatment regimen in children with CNS tumours will be included. Relevant economic evaluations will also be identified. The outcomes are survival (overall, progression-free, event-free, disease-free), local and regional control rates, short- and long-term adverse events, functional status measures and quality of survival. Two reviewers will independently screen and select studies for inclusion in the review. All interventional study designs will be eligible for inclusion in the review. However, initial scoping searches indicate the evidence base is likely to be limited to case series studies, with no studies of a higher quality being identified. Quality assessment will be undertaken using pre-specified criteria and tailored to study design if applicable. Studies will be combined using a narrative synthesis, with differences in results between studies highlighted and discussed in relation to the patient population, intervention and study quality. Where appropriate, if no studies of a comparative design are identified, outcomes will be compared against a range of estimates from the literature for similar populations and treatment regimens from the best available evidence from studies that include the use of advanced conventional photon therapy.DISCUSSION: The evidence base for the use of PBT in children with CNS tumours is likely to be relatively sparse, highly heterogeneous and potentially of a low quality with small sample sizes. Furthermore, selection and publication biases may limit the internal and external validity of studies. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015029583.",
keywords = "Children , Central nervous system tumours , Proton beam RT , Conventional photon RT , Systematic reviews",
author = "Caroline Main and Madhumita Dandapani and Mark Pritchard and Rachel Dodds and Stevens, {Simon P} and Nicky Thorp and Taylor, {Roger E} and Keith Wheatley and Barry Pizer and Matthew Morrall and Robert Phillips and Martin English and Kearns, {Pamela R} and Sophie Wilne and Wilson, {Jayne S}",
year = "2016",
month = jul,
day = "27",
doi = "10.1186/s13643-016-0285-6",
language = "English",
volume = "5",
journal = "Systematic Reviews",
issn = "2046-4053",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours

T2 - protocol for a systematic review

AU - Main, Caroline

AU - Dandapani, Madhumita

AU - Pritchard, Mark

AU - Dodds, Rachel

AU - Stevens, Simon P

AU - Thorp, Nicky

AU - Taylor, Roger E

AU - Wheatley, Keith

AU - Pizer, Barry

AU - Morrall, Matthew

AU - Phillips, Robert

AU - English, Martin

AU - Kearns, Pamela R

AU - Wilne, Sophie

AU - Wilson, Jayne S

PY - 2016/7/27

Y1 - 2016/7/27

N2 - BACKGROUND: The aim of this study is to use a systematic review framework to identify and synthesise the evidence on the use of proton beam therapy (PBT) for the treatment of children with CNS tumours and where possible compare this to the use of photon radiotherapy (RT).METHODS: Standard systematic review methods aimed at minimising bias will be employed for study identification, selection and data extraction. Twelve electronic databases have been searched, and further citation, hand searching and reference checking will be employed. Studies assessing the effects of PBT used either alone or as part of a multimodality treatment regimen in children with CNS tumours will be included. Relevant economic evaluations will also be identified. The outcomes are survival (overall, progression-free, event-free, disease-free), local and regional control rates, short- and long-term adverse events, functional status measures and quality of survival. Two reviewers will independently screen and select studies for inclusion in the review. All interventional study designs will be eligible for inclusion in the review. However, initial scoping searches indicate the evidence base is likely to be limited to case series studies, with no studies of a higher quality being identified. Quality assessment will be undertaken using pre-specified criteria and tailored to study design if applicable. Studies will be combined using a narrative synthesis, with differences in results between studies highlighted and discussed in relation to the patient population, intervention and study quality. Where appropriate, if no studies of a comparative design are identified, outcomes will be compared against a range of estimates from the literature for similar populations and treatment regimens from the best available evidence from studies that include the use of advanced conventional photon therapy.DISCUSSION: The evidence base for the use of PBT in children with CNS tumours is likely to be relatively sparse, highly heterogeneous and potentially of a low quality with small sample sizes. Furthermore, selection and publication biases may limit the internal and external validity of studies. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015029583.

AB - BACKGROUND: The aim of this study is to use a systematic review framework to identify and synthesise the evidence on the use of proton beam therapy (PBT) for the treatment of children with CNS tumours and where possible compare this to the use of photon radiotherapy (RT).METHODS: Standard systematic review methods aimed at minimising bias will be employed for study identification, selection and data extraction. Twelve electronic databases have been searched, and further citation, hand searching and reference checking will be employed. Studies assessing the effects of PBT used either alone or as part of a multimodality treatment regimen in children with CNS tumours will be included. Relevant economic evaluations will also be identified. The outcomes are survival (overall, progression-free, event-free, disease-free), local and regional control rates, short- and long-term adverse events, functional status measures and quality of survival. Two reviewers will independently screen and select studies for inclusion in the review. All interventional study designs will be eligible for inclusion in the review. However, initial scoping searches indicate the evidence base is likely to be limited to case series studies, with no studies of a higher quality being identified. Quality assessment will be undertaken using pre-specified criteria and tailored to study design if applicable. Studies will be combined using a narrative synthesis, with differences in results between studies highlighted and discussed in relation to the patient population, intervention and study quality. Where appropriate, if no studies of a comparative design are identified, outcomes will be compared against a range of estimates from the literature for similar populations and treatment regimens from the best available evidence from studies that include the use of advanced conventional photon therapy.DISCUSSION: The evidence base for the use of PBT in children with CNS tumours is likely to be relatively sparse, highly heterogeneous and potentially of a low quality with small sample sizes. Furthermore, selection and publication biases may limit the internal and external validity of studies. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015029583.

KW - Children

KW - Central nervous system tumours

KW - Proton beam RT

KW - Conventional photon RT

KW - Systematic reviews

U2 - 10.1186/s13643-016-0285-6

DO - 10.1186/s13643-016-0285-6

M3 - Article

C2 - 27460473

VL - 5

JO - Systematic Reviews

JF - Systematic Reviews

SN - 2046-4053

IS - 1

M1 - 124

ER -