The effect of regular strength training on telomere length in human skeletal muscle

Research output: Contribution to journalArticle

Authors

  • F. Kadi
  • Elodie Ponsot
  • Karin Piehl-Aulin
  • Abigail Louise Mackey
  • Michael Kjær
  • Eva Oskarsson

Colleges, School and Institutes

Abstract

PURPOSE: The length of DNA telomeres is an important parameter of the proliferative potential of tissues. A recent study has reported abnormally short telomeres in skeletal muscle of athletes with exercise-associated fatigue. This important report raises the question of whether long-term practice of sports might have deleterious effects on muscle telomeres. Therefore, we aimed to compare telomere length of a group of power lifters (PL; N = 7) who trained for 8 +/- 3 yr against that of a group of healthy, active subjects (C; N = 7) with no history of strength training. METHODS: Muscle biopsies were taken from the vastus lateralis, and the mean and minimum telomeric restriction fragments (TRF) (telomere length) were determined, using the Southern blot protocol previously used for the analysis of skeletal muscle. RESULTS: There was no abnormal shortening of telomeres in PL. On the contrary, the mean (P = 0.07) and the minimum (P = 0.09) TRF lengths in PL tended to be higher than in C. In PL, the minimum TRF length was inversely correlated to the individual records in squat (r = -0.86; P = 0.01) and deadlift (r = -0.88; P = 0.01). CONCLUSION: These results show for the first time that long-term training is not associated with an abnormal shortening of skeletal muscle telomere length. Although the minimum telomere length in PL remains within normal physiological ranges, a heavier load put on the muscles means a shorter minimum TRF length in skeletal muscle.

Bibliographic note

Keywords: Adult; Case-Control Studies; Humans; Male; Muscle Contraction; Muscle Strength; Muscle, Skeletal; Satellite Cells, Skeletal Muscle; Telomerase; Telomere; Telomeric Repeat Binding Protein 1; Weight Lifting; Weight-Bearing

Details

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume40
Issue number1
Publication statusPublished - Jan 2008