The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Research output: Contribution to journalArticle


  • S Ogoh
  • K Sato
  • T Seifert
  • M Overgaard
  • NH Secher

Colleges, School and Institutes


Aim: Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (ScO2) and increases middle cerebral artery mean blood velocity (MCA V-mean), suggesting alpha-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow. Methods: We determined ScO2, MCA V-mean, and right internal carotid artery (ICA) and internal jugular venous (IJV) blood flow (duplex ultrasound) during infusion of PE in eight supine young healthy men [26 (3) years, 177 (7) cm and 74 (8) kg; mean (SD)]. Results: Compared with saline, during infusion of PE, mean arterial pressure increased 26 +/- 3% (mean +/- SE) and MCA Vmean by 4.8 +/- 1.9% (P


Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalClinical physiology and functional imaging
Issue number6
Publication statusPublished - 1 Nov 2011


  • near-infrared spectroscopy, internal jugular venous, middle cerebral artery mean blood velocity, frontal lobe oxygenation, sympathetic nerve activity, internal carotid artery