The effect of cytotoxic lesions of the hippocampus on object recognition memory in the rat: effects of stimulus size

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The effect of cytotoxic lesions of the hippocampus on object recognition memory in the rat: effects of stimulus size. / Higgs, Suzanne; Bannerman, DM; Rawlins, JNP.

In: Behavioral Neuroscience, Vol. 115, 01.01.2001, p. 1193-1203.

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@article{283cf803e839475ea64c60498861b822,
title = "The effect of cytotoxic lesions of the hippocampus on object recognition memory in the rat: effects of stimulus size",
abstract = "Rats with excitotoxic hippocampal lesions were trained on delayed nonmatching-to-sample (DNMS) with small goal boxes, containing complex objects, presented on a pseudo trial-unique schedule. A series of experiments then tested performance on repeated presentation of either the small object or large empty goal boxes. All rats acquired the nonmatching rule, but hippocampal-lesioned rats performed less well than controls on choice accuracy for the final 2 blocks of acquisition. In the study's main phase, the lesions impaired choice accuracy when the large empty boxes were used as stimuli. This deficit was ameliorated when the rats were tested with the small object boxes, although the performance of the hippocampal-lesioned rats was still below that of controls. These results extend previous reports of box size-dependent effects of hippocampal aspiration lesions on DNMS and suggest that selective damage to the hippocampus, not neuronal loss in adjacent structures or fiber tracts, is critical for the effect.",
author = "Suzanne Higgs and DM Bannerman and JNP Rawlins",
year = "2001",
month = jan,
day = "1",
doi = "10.1037/0735-7044.115.6.1193",
language = "English",
volume = "115",
pages = "1193--1203",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association",

}

RIS

TY - JOUR

T1 - The effect of cytotoxic lesions of the hippocampus on object recognition memory in the rat: effects of stimulus size

AU - Higgs, Suzanne

AU - Bannerman, DM

AU - Rawlins, JNP

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Rats with excitotoxic hippocampal lesions were trained on delayed nonmatching-to-sample (DNMS) with small goal boxes, containing complex objects, presented on a pseudo trial-unique schedule. A series of experiments then tested performance on repeated presentation of either the small object or large empty goal boxes. All rats acquired the nonmatching rule, but hippocampal-lesioned rats performed less well than controls on choice accuracy for the final 2 blocks of acquisition. In the study's main phase, the lesions impaired choice accuracy when the large empty boxes were used as stimuli. This deficit was ameliorated when the rats were tested with the small object boxes, although the performance of the hippocampal-lesioned rats was still below that of controls. These results extend previous reports of box size-dependent effects of hippocampal aspiration lesions on DNMS and suggest that selective damage to the hippocampus, not neuronal loss in adjacent structures or fiber tracts, is critical for the effect.

AB - Rats with excitotoxic hippocampal lesions were trained on delayed nonmatching-to-sample (DNMS) with small goal boxes, containing complex objects, presented on a pseudo trial-unique schedule. A series of experiments then tested performance on repeated presentation of either the small object or large empty goal boxes. All rats acquired the nonmatching rule, but hippocampal-lesioned rats performed less well than controls on choice accuracy for the final 2 blocks of acquisition. In the study's main phase, the lesions impaired choice accuracy when the large empty boxes were used as stimuli. This deficit was ameliorated when the rats were tested with the small object boxes, although the performance of the hippocampal-lesioned rats was still below that of controls. These results extend previous reports of box size-dependent effects of hippocampal aspiration lesions on DNMS and suggest that selective damage to the hippocampus, not neuronal loss in adjacent structures or fiber tracts, is critical for the effect.

U2 - 10.1037/0735-7044.115.6.1193

DO - 10.1037/0735-7044.115.6.1193

M3 - Article

C2 - 11770051

VL - 115

SP - 1193

EP - 1203

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

ER -