The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise

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The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise. / Robson-Ansley, P; Walshe, I; Ward, Douglas.

In: Cytokine, Vol. 53, No. 2, 01.02.2011, p. 196-200.

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@article{bc1e735869794cdb8255a616b2bb03b1,
title = "The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise",
abstract = "The aim of our study was twofold, firstly to examine the relationship between plasma concentrations of IL-6, hepcidin and iron following prolonged exercise and secondly, to assess the effect of carbohydrate ingestion on circulating hepcidin concentration post-exercise. The study was a randomised double-blind cross-over design, with participants consuming either a carbohydrate (CHO) or an isovolumetric placebo drink throughout the trial. Nine healthy, trained males completed a treadmill run at 60% nu VO2max for 120 min followed by a 5 km time trial. Plasma concentrations of both IL-6 and hepcidin significantly increased post-exercise following both trials (p <.05) and returned to baseline by 24 h post (p > .05). A positive correlation between hepcidin and IL-6 was demonstrated immediately following exercise during PLA while there was a trend for a moderate correlation during CHO (PLA trial rho = 0.81, p <0.001: CHO trial rho = 0.36, p = 0.07). Plasma iron was unaffected immediately post-exercise but significantly reduced by 24 h post-exercise compared to baseline. CHO ingestion significantly reduced post-exercise IL-6 (p <.05) but this had no effect on plasma hepcidin or iron concentration. Our data demonstrate CHO supplementation does not alter the rapid hepcidin response associated with exercise and does not prevent a subsequent fall in plasma iron concentration. This finding adds further support to the theory that an exercise-induced, up-regulation of hepcidin activity is a mechanism causing iron deficiency in endurance athletes. (C) 2010 Elsevier Ltd. All rights reserved.",
keywords = "Aerobic exercise, Interleukin-6, Carbohydrate, Hepcidin, Inflammation",
author = "P Robson-Ansley and I Walshe and Douglas Ward",
year = "2011",
month = feb,
day = "1",
doi = "10.1016/j.cyto.2010.10.001",
language = "English",
volume = "53",
pages = "196--200",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise

AU - Robson-Ansley, P

AU - Walshe, I

AU - Ward, Douglas

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The aim of our study was twofold, firstly to examine the relationship between plasma concentrations of IL-6, hepcidin and iron following prolonged exercise and secondly, to assess the effect of carbohydrate ingestion on circulating hepcidin concentration post-exercise. The study was a randomised double-blind cross-over design, with participants consuming either a carbohydrate (CHO) or an isovolumetric placebo drink throughout the trial. Nine healthy, trained males completed a treadmill run at 60% nu VO2max for 120 min followed by a 5 km time trial. Plasma concentrations of both IL-6 and hepcidin significantly increased post-exercise following both trials (p <.05) and returned to baseline by 24 h post (p > .05). A positive correlation between hepcidin and IL-6 was demonstrated immediately following exercise during PLA while there was a trend for a moderate correlation during CHO (PLA trial rho = 0.81, p <0.001: CHO trial rho = 0.36, p = 0.07). Plasma iron was unaffected immediately post-exercise but significantly reduced by 24 h post-exercise compared to baseline. CHO ingestion significantly reduced post-exercise IL-6 (p <.05) but this had no effect on plasma hepcidin or iron concentration. Our data demonstrate CHO supplementation does not alter the rapid hepcidin response associated with exercise and does not prevent a subsequent fall in plasma iron concentration. This finding adds further support to the theory that an exercise-induced, up-regulation of hepcidin activity is a mechanism causing iron deficiency in endurance athletes. (C) 2010 Elsevier Ltd. All rights reserved.

AB - The aim of our study was twofold, firstly to examine the relationship between plasma concentrations of IL-6, hepcidin and iron following prolonged exercise and secondly, to assess the effect of carbohydrate ingestion on circulating hepcidin concentration post-exercise. The study was a randomised double-blind cross-over design, with participants consuming either a carbohydrate (CHO) or an isovolumetric placebo drink throughout the trial. Nine healthy, trained males completed a treadmill run at 60% nu VO2max for 120 min followed by a 5 km time trial. Plasma concentrations of both IL-6 and hepcidin significantly increased post-exercise following both trials (p <.05) and returned to baseline by 24 h post (p > .05). A positive correlation between hepcidin and IL-6 was demonstrated immediately following exercise during PLA while there was a trend for a moderate correlation during CHO (PLA trial rho = 0.81, p <0.001: CHO trial rho = 0.36, p = 0.07). Plasma iron was unaffected immediately post-exercise but significantly reduced by 24 h post-exercise compared to baseline. CHO ingestion significantly reduced post-exercise IL-6 (p <.05) but this had no effect on plasma hepcidin or iron concentration. Our data demonstrate CHO supplementation does not alter the rapid hepcidin response associated with exercise and does not prevent a subsequent fall in plasma iron concentration. This finding adds further support to the theory that an exercise-induced, up-regulation of hepcidin activity is a mechanism causing iron deficiency in endurance athletes. (C) 2010 Elsevier Ltd. All rights reserved.

KW - Aerobic exercise

KW - Interleukin-6

KW - Carbohydrate

KW - Hepcidin

KW - Inflammation

U2 - 10.1016/j.cyto.2010.10.001

DO - 10.1016/j.cyto.2010.10.001

M3 - Article

C2 - 21095135

VL - 53

SP - 196

EP - 200

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 2

ER -