The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study

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The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men : A pilot study. / Narang, Ben J.; Wallis, Gareth A.; Gonzalez, Javier T.

In: European Journal of Sport Science, 2020.

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@article{49d93bee45764439b21a51c2c4a4c2eb,
title = "The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study",
abstract = "The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min−1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min−1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min−1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men. Highlights Exogenous glucose oxidation rates during exercise are thought to be limited by intestinal glucose absorption. Previous work has suggested that calcium may facilitate GLUT2 translocation in rodent intestine, revealing the possibility that calcium could enhance intestinal glucose absorption. Data from the present study suggest that, in humans, ingesting calcium alongside glucose at saturating glucose absorption rates, does not enhance exogenous glucose oxidation rates during exercise.",
keywords = "Calcium, carbohydrate, endurance exercise, exogenous glucose oxidation, intestinal absorption, metabolism, sports nutrition",
author = "Narang, {Ben J.} and Wallis, {Gareth A.} and Gonzalez, {Javier T.}",
year = "2020",
doi = "10.1080/17461391.2020.1813336",
language = "English",
journal = "European Journal of Sport Science",
issn = "1746-1391",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men

T2 - A pilot study

AU - Narang, Ben J.

AU - Wallis, Gareth A.

AU - Gonzalez, Javier T.

PY - 2020

Y1 - 2020

N2 - The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min−1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min−1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min−1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men. Highlights Exogenous glucose oxidation rates during exercise are thought to be limited by intestinal glucose absorption. Previous work has suggested that calcium may facilitate GLUT2 translocation in rodent intestine, revealing the possibility that calcium could enhance intestinal glucose absorption. Data from the present study suggest that, in humans, ingesting calcium alongside glucose at saturating glucose absorption rates, does not enhance exogenous glucose oxidation rates during exercise.

AB - The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min−1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min−1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min−1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men. Highlights Exogenous glucose oxidation rates during exercise are thought to be limited by intestinal glucose absorption. Previous work has suggested that calcium may facilitate GLUT2 translocation in rodent intestine, revealing the possibility that calcium could enhance intestinal glucose absorption. Data from the present study suggest that, in humans, ingesting calcium alongside glucose at saturating glucose absorption rates, does not enhance exogenous glucose oxidation rates during exercise.

KW - Calcium

KW - carbohydrate

KW - endurance exercise

KW - exogenous glucose oxidation

KW - intestinal absorption

KW - metabolism

KW - sports nutrition

UR - http://www.scopus.com/inward/record.url?scp=85090977405&partnerID=8YFLogxK

U2 - 10.1080/17461391.2020.1813336

DO - 10.1080/17461391.2020.1813336

M3 - Article

AN - SCOPUS:85090977405

JO - European Journal of Sport Science

JF - European Journal of Sport Science

SN - 1746-1391

ER -