The effect of BDNF val66met polymorphism on visuomotor adaptation

Research output: Contribution to journalArticle


  • Raed A Joundi
  • Virginia Lopez-Alonso
  • Angel Lago
  • John-Stuart Brittain
  • Miguel Fernandez-Del-Olmo
  • Pilar Gomez-Garre
  • Pablo Mir
  • Binith Cheeran
  • Peter Brown

Colleges, School and Institutes

External organisations

  • Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK.


Brain-derived neurotrophic factor (BDNF) plays an important role in learning, memory, and brain plasticity. Humans with a val66met polymorphism in the BDNF gene have reduced levels of BDNF and alterations in motor learning and short-term cortical plasticity. In the current study, we sought to further explore the role of BDNF in motor learning by testing human subjects on a visuomotor adaptation task. In experiment 1, 21 subjects with the polymorphism (val/met) and 21 matched controls (val/val) were tested during learning, short-term retention (45 min), long-term retention (24 h), and de-adaptation of a 60° visuomotor deviation. We measured both mean error as well as rate of adaptation during each session. There was no difference in mean error between groups; however, val/met subjects had a reduced rate of adaptation during learning as well as during long-term retention, but not short-term retention or de-adaptation. In experiment 2, 12 val/met and 12 val/val subjects were tested on a larger 80° deviation, revealing a more pronounced difference in mean error during adaptation than the 60° deviation. These results suggest that BDNF may play an important role in visuomotor adaptive processes in the human.


Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalExperimental Brain Research
Issue number1
Publication statusPublished - Nov 2012


  • Adaptation, Physiological, Amino Acid Substitution, Analysis of Variance, Brain-Derived Neurotrophic Factor, Data Interpretation, Statistical, Female, Genotype, Humans, Learning, Male, Polymorphism, Genetic, Psychomotor Performance, Young Adult, Journal Article, Research Support, Non-U.S. Gov't