The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations.

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The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations. / Lu, CB; Vreugdenhil, Martin; Toescu, Emil.

In: Neurobiology of Aging, Vol. 33, No. 11, 11.2012, p. 2692–2703.

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@article{53c49fcfd9df47a8bf809e395d9c59d2,
title = "The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations.",
abstract = "Oscillations in hippocampal neuronal networks in the gamma frequency band have been implicated in various cognitive tasks and we showed previously that aging reduces the power of such oscillations. Here, using submerged hippocampal slices allowing simultaneous electrophysiological recordings and imaging, we studied the correlation between the kainate-evoked gamma oscillation and mitochondrial activity, as monitored by rhodamine 123. We show that the initiation of kainate-evoked gamma oscillations induces mitochondrial depolarization, indicating a metabolic response. Aging had an opposite effect on these parameters: while depressing the gamma oscillation strength, it increases mitochondrial depolarization. Also, in the aged neurons, kainate induced significantly larger Ca(2+) signals. In younger slices, acute mitochondrial depolarization induced by low concentrations of mitochondrial protonophores strongly, but reversibly, inhibits gamma oscillations. These data indicating that the complex network activity required by the maintenance of gamma activity is susceptible to changes and modulations in mitochondrial status.",
keywords = "Gamma oscillations, Kainate, Mitochondrial depolarization, Calcium signal, Mitochondrial protonophore",
author = "CB Lu and Martin Vreugdenhil and Emil Toescu",
year = "2012",
month = nov,
doi = "10.1016/j.neurobiolaging.2012.01.001",
language = "English",
volume = "33",
pages = "2692–2703",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations.

AU - Lu, CB

AU - Vreugdenhil, Martin

AU - Toescu, Emil

PY - 2012/11

Y1 - 2012/11

N2 - Oscillations in hippocampal neuronal networks in the gamma frequency band have been implicated in various cognitive tasks and we showed previously that aging reduces the power of such oscillations. Here, using submerged hippocampal slices allowing simultaneous electrophysiological recordings and imaging, we studied the correlation between the kainate-evoked gamma oscillation and mitochondrial activity, as monitored by rhodamine 123. We show that the initiation of kainate-evoked gamma oscillations induces mitochondrial depolarization, indicating a metabolic response. Aging had an opposite effect on these parameters: while depressing the gamma oscillation strength, it increases mitochondrial depolarization. Also, in the aged neurons, kainate induced significantly larger Ca(2+) signals. In younger slices, acute mitochondrial depolarization induced by low concentrations of mitochondrial protonophores strongly, but reversibly, inhibits gamma oscillations. These data indicating that the complex network activity required by the maintenance of gamma activity is susceptible to changes and modulations in mitochondrial status.

AB - Oscillations in hippocampal neuronal networks in the gamma frequency band have been implicated in various cognitive tasks and we showed previously that aging reduces the power of such oscillations. Here, using submerged hippocampal slices allowing simultaneous electrophysiological recordings and imaging, we studied the correlation between the kainate-evoked gamma oscillation and mitochondrial activity, as monitored by rhodamine 123. We show that the initiation of kainate-evoked gamma oscillations induces mitochondrial depolarization, indicating a metabolic response. Aging had an opposite effect on these parameters: while depressing the gamma oscillation strength, it increases mitochondrial depolarization. Also, in the aged neurons, kainate induced significantly larger Ca(2+) signals. In younger slices, acute mitochondrial depolarization induced by low concentrations of mitochondrial protonophores strongly, but reversibly, inhibits gamma oscillations. These data indicating that the complex network activity required by the maintenance of gamma activity is susceptible to changes and modulations in mitochondrial status.

KW - Gamma oscillations

KW - Kainate

KW - Mitochondrial depolarization

KW - Calcium signal

KW - Mitochondrial protonophore

U2 - 10.1016/j.neurobiolaging.2012.01.001

DO - 10.1016/j.neurobiolaging.2012.01.001

M3 - Article

C2 - 22405041

VL - 33

SP - 2692

EP - 2703

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 11

ER -