The effect of a triclosan-containing dentifrice on the progression of periodontal disease in an adult population

Research output: Contribution to journalArticle


  • MP Cullinan
  • B Westerman
  • SM Hamlet
  • JE Palmer
  • GJ Seymour

Colleges, School and Institutes


Objectives: The aim of the present study was to determine the effect of unsupervised, long-term use of a 0.3% triclosan/2% copolymer dentifrice on the progression of periodontal disease in a general adult population. Methods: Five hundred and four volunteers were enrolled in a double-blind, controlled clinical trial. Participants were matched for disease status, plaque index, age and gender. At the baseline examination, probing pocket depths and relative attachment levels were recorded and participants were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months. Subgingival plaque samples were collected at each examination and assayed for Porphyromonas gingivalis , Actinobacillus actinomycetemcomitans and Prevotella intermedia . A generalised linear model was used to analyse the data, with a number of covariates thought to influence the responses included as the possible confounding effects. Results: The triclosan/copolymer dentifrice had a significant effect in subjects with interproximal probing depths greater than or equal to3.5 mm, where it significantly reduced the number of sites with probing depths greater than or equal to3.5 mm at the following examination, when compared with the control group (p


Original languageEnglish
Pages (from-to)414-419
Number of pages6
JournalJournal of Clinical Periodontology
Issue number5
Publication statusPublished - 1 May 2003


  • attachment loss, probing pocket depths, triclosan, periodontal disease, periodontitis progression