The ecology and evolution of pangenomes

Research output: Contribution to journalReview article

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The ecology and evolution of pangenomes. / Brockhurst, Michael A; Harrison, Ellie; Hall, James P J; Richards, Thomas; McNally, Alan; MacLean, Craig.

In: Current Biology, Vol. 29, No. 20, 21.10.2019, p. R1094-R1103.

Research output: Contribution to journalReview article

Harvard

Brockhurst, MA, Harrison, E, Hall, JPJ, Richards, T, McNally, A & MacLean, C 2019, 'The ecology and evolution of pangenomes', Current Biology, vol. 29, no. 20, pp. R1094-R1103. https://doi.org/10.1016/j.cub.2019.08.012

APA

Brockhurst, M. A., Harrison, E., Hall, J. P. J., Richards, T., McNally, A., & MacLean, C. (2019). The ecology and evolution of pangenomes. Current Biology, 29(20), R1094-R1103. https://doi.org/10.1016/j.cub.2019.08.012

Vancouver

Brockhurst MA, Harrison E, Hall JPJ, Richards T, McNally A, MacLean C. The ecology and evolution of pangenomes. Current Biology. 2019 Oct 21;29(20):R1094-R1103. https://doi.org/10.1016/j.cub.2019.08.012

Author

Brockhurst, Michael A ; Harrison, Ellie ; Hall, James P J ; Richards, Thomas ; McNally, Alan ; MacLean, Craig. / The ecology and evolution of pangenomes. In: Current Biology. 2019 ; Vol. 29, No. 20. pp. R1094-R1103.

Bibtex

@article{a7f5aa36096248e9b4a8b06aa20e5549,
title = "The ecology and evolution of pangenomes",
abstract = "Since the first genome-scale comparisons, it has been evident that the genomes of many species are unbound by strict vertical descent: Large differences in gene content can occur among genomes belonging to the same prokaryotic species, with only a fraction of genes being universal to all genomes. These insights gave rise to the pangenome concept. The pangenome is defined as the set of all the genes present in a given species and can be subdivided into the accessory genome, present in only some of the genomes, and the core genome, present in all the genomes. Pangenomes arise due to gene gain by genomes from other species through horizontal gene transfer and differential gene loss among genomes, and have been described in both prokaryotes and eukaryotes. Our current view of pangenome variation is phenomenological and incomplete. In this review, we outline the mechanistic, ecological and evolutionary drivers of and barriers to horizontal gene transfer that are likely to structure pangenomes. We highlight the key role of conflict between the host chromosome(s) and the mobile genetic elements that mediate gene exchange. We identify shortcomings in our current models of pangenome evolution and suggest directions for future research to allow a more complete understanding of how and why pangenomes evolve.",
author = "Brockhurst, {Michael A} and Ellie Harrison and Hall, {James P J} and Thomas Richards and Alan McNally and Craig MacLean",
year = "2019",
month = oct,
day = "21",
doi = "10.1016/j.cub.2019.08.012",
language = "English",
volume = "29",
pages = "R1094--R1103",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Elsevier",
number = "20",

}

RIS

TY - JOUR

T1 - The ecology and evolution of pangenomes

AU - Brockhurst, Michael A

AU - Harrison, Ellie

AU - Hall, James P J

AU - Richards, Thomas

AU - McNally, Alan

AU - MacLean, Craig

PY - 2019/10/21

Y1 - 2019/10/21

N2 - Since the first genome-scale comparisons, it has been evident that the genomes of many species are unbound by strict vertical descent: Large differences in gene content can occur among genomes belonging to the same prokaryotic species, with only a fraction of genes being universal to all genomes. These insights gave rise to the pangenome concept. The pangenome is defined as the set of all the genes present in a given species and can be subdivided into the accessory genome, present in only some of the genomes, and the core genome, present in all the genomes. Pangenomes arise due to gene gain by genomes from other species through horizontal gene transfer and differential gene loss among genomes, and have been described in both prokaryotes and eukaryotes. Our current view of pangenome variation is phenomenological and incomplete. In this review, we outline the mechanistic, ecological and evolutionary drivers of and barriers to horizontal gene transfer that are likely to structure pangenomes. We highlight the key role of conflict between the host chromosome(s) and the mobile genetic elements that mediate gene exchange. We identify shortcomings in our current models of pangenome evolution and suggest directions for future research to allow a more complete understanding of how and why pangenomes evolve.

AB - Since the first genome-scale comparisons, it has been evident that the genomes of many species are unbound by strict vertical descent: Large differences in gene content can occur among genomes belonging to the same prokaryotic species, with only a fraction of genes being universal to all genomes. These insights gave rise to the pangenome concept. The pangenome is defined as the set of all the genes present in a given species and can be subdivided into the accessory genome, present in only some of the genomes, and the core genome, present in all the genomes. Pangenomes arise due to gene gain by genomes from other species through horizontal gene transfer and differential gene loss among genomes, and have been described in both prokaryotes and eukaryotes. Our current view of pangenome variation is phenomenological and incomplete. In this review, we outline the mechanistic, ecological and evolutionary drivers of and barriers to horizontal gene transfer that are likely to structure pangenomes. We highlight the key role of conflict between the host chromosome(s) and the mobile genetic elements that mediate gene exchange. We identify shortcomings in our current models of pangenome evolution and suggest directions for future research to allow a more complete understanding of how and why pangenomes evolve.

UR - http://www.scopus.com/inward/record.url?scp=85073435031&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2019.08.012

DO - 10.1016/j.cub.2019.08.012

M3 - Review article

C2 - 31639358

VL - 29

SP - R1094-R1103

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 20

ER -