The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior

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The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior. / Doncom, Kay E. B.; Willcock, Helen; O'Reilly, Rachel K.

In: European Polymer Journal, Vol. 87, 01.02.2017, p. 497-507.

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@article{5da06f3767d248ce9b12d920555f6daf,
title = "The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior",
abstract = "Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers self-assembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles.",
keywords = "sulfobetaines, thermo-responsive polymers, self-assembly, controlled release, static light scattering",
author = "Doncom, {Kay E. B.} and Helen Willcock and O'Reilly, {Rachel K.}",
year = "2017",
month = feb,
day = "1",
doi = "10.1016/j.eurpolymj.2016.09.002",
language = "English",
volume = "87",
pages = "497--507",
journal = "European Polymer Journal",
issn = "0014-3057",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior

AU - Doncom, Kay E. B.

AU - Willcock, Helen

AU - O'Reilly, Rachel K.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers self-assembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles.

AB - Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers self-assembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles.

KW - sulfobetaines

KW - thermo-responsive polymers

KW - self-assembly

KW - controlled release

KW - static light scattering

U2 - 10.1016/j.eurpolymj.2016.09.002

DO - 10.1016/j.eurpolymj.2016.09.002

M3 - Article

VL - 87

SP - 497

EP - 507

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -