The Contribution of Leucocytes to the Antimicrobial Activity of Platelet Rich Plasma Preparations: a systematic review

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The Contribution of Leucocytes to the Antimicrobial Activity of Platelet Rich Plasma Preparations: a systematic review. / D'Asta, Federica; Webber, Mark; Bishop, Jon; Halstead, Fenella; Moiemen, Naiem; Lord, Janet; Harrison, Paul.

In: Platelets, 06.07.2017.

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@article{c839d8008e204a01bc24c911eb0a8b97,
title = "The Contribution of Leucocytes to the Antimicrobial Activity of Platelet Rich Plasma Preparations: a systematic review",
abstract = "The infection of a wound is one of the major contributors to delays in healing and tissue regeneration. As multi-drug resistance to antibiotics is becoming a serious threat, research in this field has focused on finding new agents and strategies to fight infection and additionally to reduce healing times. The topical use of autologous Platelet Rich Plasma (PRP) as a biological accelerator of the healing process, has been safely used as a form of treatment for wounds since the 1990s. Although the presence or absence of leucocytes in PRP preparation was previously neglected, in the last decade more attention has been paid to their role and several studies have been conducted to explore both their immuno-metabolic effects and their antimicrobial properties. In this review, we aim to summarise the literature on the contribution of leucocytes included in PRP preparations in terms of their antimicrobial properties. This should help to inform clinical practice and additional research in this promising field.",
keywords = "leucocytes, platelet concentrate, PRP, L-PRP, LPRF, Leucopatch",
author = "Federica D'Asta and Mark Webber and Jon Bishop and Fenella Halstead and Naiem Moiemen and Janet Lord and Paul Harrison",
year = "2017",
month = jul,
day = "6",
doi = "10.1080/09537104.2017.1317731",
language = "English",
journal = "Platelets",
issn = "0953-7104",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - The Contribution of Leucocytes to the Antimicrobial Activity of Platelet Rich Plasma Preparations: a systematic review

AU - D'Asta, Federica

AU - Webber, Mark

AU - Bishop, Jon

AU - Halstead, Fenella

AU - Moiemen, Naiem

AU - Lord, Janet

AU - Harrison, Paul

PY - 2017/7/6

Y1 - 2017/7/6

N2 - The infection of a wound is one of the major contributors to delays in healing and tissue regeneration. As multi-drug resistance to antibiotics is becoming a serious threat, research in this field has focused on finding new agents and strategies to fight infection and additionally to reduce healing times. The topical use of autologous Platelet Rich Plasma (PRP) as a biological accelerator of the healing process, has been safely used as a form of treatment for wounds since the 1990s. Although the presence or absence of leucocytes in PRP preparation was previously neglected, in the last decade more attention has been paid to their role and several studies have been conducted to explore both their immuno-metabolic effects and their antimicrobial properties. In this review, we aim to summarise the literature on the contribution of leucocytes included in PRP preparations in terms of their antimicrobial properties. This should help to inform clinical practice and additional research in this promising field.

AB - The infection of a wound is one of the major contributors to delays in healing and tissue regeneration. As multi-drug resistance to antibiotics is becoming a serious threat, research in this field has focused on finding new agents and strategies to fight infection and additionally to reduce healing times. The topical use of autologous Platelet Rich Plasma (PRP) as a biological accelerator of the healing process, has been safely used as a form of treatment for wounds since the 1990s. Although the presence or absence of leucocytes in PRP preparation was previously neglected, in the last decade more attention has been paid to their role and several studies have been conducted to explore both their immuno-metabolic effects and their antimicrobial properties. In this review, we aim to summarise the literature on the contribution of leucocytes included in PRP preparations in terms of their antimicrobial properties. This should help to inform clinical practice and additional research in this promising field.

KW - leucocytes

KW - platelet concentrate

KW - PRP

KW - L-PRP

KW - LPRF

KW - Leucopatch

U2 - 10.1080/09537104.2017.1317731

DO - 10.1080/09537104.2017.1317731

M3 - Article

JO - Platelets

JF - Platelets

SN - 0953-7104

ER -