The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration

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The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. / Makuloluwa, Aruni K; Hamill, Kevin J; Rauz, Saaeha; Bosworth, Lucy; Haneef, Atikah; Romano, Vito; Williams, Rachel L; Dartt, Darlene A; Kaye, Stephen B.

In: Ocular Surface, 05.06.2021.

Research output: Contribution to journalReview articlepeer-review

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APA

Makuloluwa, A. K., Hamill, K. J., Rauz, S., Bosworth, L., Haneef, A., Romano, V., Williams, R. L., Dartt, D. A., & Kaye, S. B. (2021). The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. Ocular Surface. https://doi.org/10.1016/j.jtos.2021.05.011

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Author

Makuloluwa, Aruni K ; Hamill, Kevin J ; Rauz, Saaeha ; Bosworth, Lucy ; Haneef, Atikah ; Romano, Vito ; Williams, Rachel L ; Dartt, Darlene A ; Kaye, Stephen B. / The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. In: Ocular Surface. 2021.

Bibtex

@article{7380674a96bd4e85aeb86a6fc6baf931,
title = "The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration",
abstract = "The conjunctiva can be damaged by numerous diseases with scarring, loss of tissue and dysfunction. Depending on extent of damage, restoration of function may require a conjunctival graft. A wide variety of biological and synthetic substrates have been tested in the search for optimal conditions for ex vivo culture of conjunctival epithelial cells as a route toward tissue grafts. Each substrate has specific advantages but also disadvantages related to their unique physical and biological characteristics, and identification and development of an improved substrate remains a priority. To achieve the goal of mimicking and restoring a biological material, requires information from the material. Specifically, extracellular matrix (ECM) derived from conjunctival tissue. Knowledge of the composition and structure of native ECM and identifying contributions of individual components to its function would enable using or mimicking those components to develop improved biological substrates. ECM is comprised of two components: basement membrane secreted predominantly by epithelial cells containing laminins and type IV collagens, which directly support epithelial and goblet cell adhesion differentiation and growth and, interstitial matrix secreted by fibroblasts in lamina propria, which provides mechanical and structural support. This review presents current knowledge on anatomy, composition of conjunctival ECM and related conjunctival disorders. Requirements of potential substrates for conjunctival tissue engineering and transplantation are discussed. Biological and synthetic substrates and their components are described in an accompanying review.",
keywords = "Basement membrane, Extracellular matrix, Conjunctiva, Tissue engineering",
author = "Makuloluwa, {Aruni K} and Hamill, {Kevin J} and Saaeha Rauz and Lucy Bosworth and Atikah Haneef and Vito Romano and Williams, {Rachel L} and Dartt, {Darlene A} and Kaye, {Stephen B}",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",
year = "2021",
month = jun,
day = "5",
doi = "10.1016/j.jtos.2021.05.011",
language = "English",
journal = "Ocular Surface",
issn = "1542-0124",
publisher = "Ethis Communications, Inc.",

}

RIS

TY - JOUR

T1 - The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration

AU - Makuloluwa, Aruni K

AU - Hamill, Kevin J

AU - Rauz, Saaeha

AU - Bosworth, Lucy

AU - Haneef, Atikah

AU - Romano, Vito

AU - Williams, Rachel L

AU - Dartt, Darlene A

AU - Kaye, Stephen B

N1 - Copyright © 2021. Published by Elsevier Inc.

PY - 2021/6/5

Y1 - 2021/6/5

N2 - The conjunctiva can be damaged by numerous diseases with scarring, loss of tissue and dysfunction. Depending on extent of damage, restoration of function may require a conjunctival graft. A wide variety of biological and synthetic substrates have been tested in the search for optimal conditions for ex vivo culture of conjunctival epithelial cells as a route toward tissue grafts. Each substrate has specific advantages but also disadvantages related to their unique physical and biological characteristics, and identification and development of an improved substrate remains a priority. To achieve the goal of mimicking and restoring a biological material, requires information from the material. Specifically, extracellular matrix (ECM) derived from conjunctival tissue. Knowledge of the composition and structure of native ECM and identifying contributions of individual components to its function would enable using or mimicking those components to develop improved biological substrates. ECM is comprised of two components: basement membrane secreted predominantly by epithelial cells containing laminins and type IV collagens, which directly support epithelial and goblet cell adhesion differentiation and growth and, interstitial matrix secreted by fibroblasts in lamina propria, which provides mechanical and structural support. This review presents current knowledge on anatomy, composition of conjunctival ECM and related conjunctival disorders. Requirements of potential substrates for conjunctival tissue engineering and transplantation are discussed. Biological and synthetic substrates and their components are described in an accompanying review.

AB - The conjunctiva can be damaged by numerous diseases with scarring, loss of tissue and dysfunction. Depending on extent of damage, restoration of function may require a conjunctival graft. A wide variety of biological and synthetic substrates have been tested in the search for optimal conditions for ex vivo culture of conjunctival epithelial cells as a route toward tissue grafts. Each substrate has specific advantages but also disadvantages related to their unique physical and biological characteristics, and identification and development of an improved substrate remains a priority. To achieve the goal of mimicking and restoring a biological material, requires information from the material. Specifically, extracellular matrix (ECM) derived from conjunctival tissue. Knowledge of the composition and structure of native ECM and identifying contributions of individual components to its function would enable using or mimicking those components to develop improved biological substrates. ECM is comprised of two components: basement membrane secreted predominantly by epithelial cells containing laminins and type IV collagens, which directly support epithelial and goblet cell adhesion differentiation and growth and, interstitial matrix secreted by fibroblasts in lamina propria, which provides mechanical and structural support. This review presents current knowledge on anatomy, composition of conjunctival ECM and related conjunctival disorders. Requirements of potential substrates for conjunctival tissue engineering and transplantation are discussed. Biological and synthetic substrates and their components are described in an accompanying review.

KW - Basement membrane

KW - Extracellular matrix

KW - Conjunctiva

KW - Tissue engineering

U2 - 10.1016/j.jtos.2021.05.011

DO - 10.1016/j.jtos.2021.05.011

M3 - Review article

C2 - 34102309

JO - Ocular Surface

JF - Ocular Surface

SN - 1542-0124

ER -