The complexity of nanoparticle dissolution and its importance in nanotoxicological studies

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The complexity of nanoparticle dissolution and its importance in nanotoxicological studies. / Misra, Superb K; Dybowska, Agnieszka; Berhanu, Deborah; Luoma, Samuel N; Valsami-Jones, Eugenia.

In: Science of the Total Environment, Vol. 438, 01.11.2012, p. 225-32.

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@article{f99e231b854d4ed785ce0050dc5c9224,
title = "The complexity of nanoparticle dissolution and its importance in nanotoxicological studies",
abstract = "Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.",
keywords = "Biological Transport, Membrane Transport Proteins, Nanoparticles, Particle Size, Solubility, Surface Properties",
author = "Misra, {Superb K} and Agnieszka Dybowska and Deborah Berhanu and Luoma, {Samuel N} and Eugenia Valsami-Jones",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
month = "11",
day = "1",
doi = "10.1016/j.scitotenv.2012.08.066",
language = "English",
volume = "438",
pages = "225--32",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The complexity of nanoparticle dissolution and its importance in nanotoxicological studies

AU - Misra, Superb K

AU - Dybowska, Agnieszka

AU - Berhanu, Deborah

AU - Luoma, Samuel N

AU - Valsami-Jones, Eugenia

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.

AB - Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.

KW - Biological Transport

KW - Membrane Transport Proteins

KW - Nanoparticles

KW - Particle Size

KW - Solubility

KW - Surface Properties

U2 - 10.1016/j.scitotenv.2012.08.066

DO - 10.1016/j.scitotenv.2012.08.066

M3 - Article

C2 - 23000548

VL - 438

SP - 225

EP - 232

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -