The cognitive neuropsychiatry of Tourette syndrome
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- Department of Neuropsychiatry, The Barberry, Birmingham, UK
- Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, UK.
- Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London
- Department of Clinical and Movement Neuroscience, Queen Square Institute of Neurology, University College London, London, UK.
- School of Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom.
- Aston University
- ASTON UNIVERSITY
- Department of Medicine/Rheumatology and Clinical Immunology and DRFZ, Charite University Hospital Berlin, Berlin, Germany.
- Groupe Hospitalier Pitié-Salpêtrière
- Hotchkiss Brain Institute, Department of Cell Biology and Anatomy and Department of Psychiatry, Cumming School of Medicine, University of Calgary
- Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; (i)Alberta Inflammatory Bowel Disease Consortium, University of Calgary, Calgary, Alberta, Canada. Electronic address: firstname.lastname@example.org.
Introduction: Converging evidence from both clinical and experimental studies has shown that Tourette syndrome (TS) is not a unitary condition, but a cluster of multiple phenotypes, which encompass both tics and specific behavioural and cognitive symptoms (mainly attention-deficit and hyperactivity disorder and obsessive-compulsive disorder). Methods: We conducted a narrative review of the recent literature on the cognitive neuropsychiatry of TS. Results: Although clinical research has shown that TS is not associated with cognitive deficits per se, the findings of recent studies have suggested the presence of subtle alterations in specific cognitive functions. A promising line of research on imitative behaviour could provide a common background for the alterations in executive control and social cognition observed in TS. Two different (but not mutually exclusive) neurocognitive theories have recently suggested that TS could originate from altered perception-action binding and social decision-making dysfunction, respectively. Conclusions: Since the presence of behavioural comorbidities influences individualised treatment approaches, it is likely that a more precise characterisation of TS phenotypes, including cognitive aspects, will result in improved levels of care for patients with tic disorders.
|Number of pages||15|
|Publication status||Published - Jul 2020|
- Attention Deficit Disorder with Hyperactivity/diagnosis, Cognition/physiology, Cognitive Dysfunction/diagnosis, Executive Function/physiology, Female, Humans, Male, Mental Status and Dementia Tests, Obsessive-Compulsive Disorder/diagnosis, Tourette Syndrome/diagnosis