The characterisation and determinants of quality of life in ANCA associated vasculitis

Research output: Contribution to journalArticle

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The characterisation and determinants of quality of life in ANCA associated vasculitis. / Basu, Neil; McClean, Andrew; Harper, Lorraine; Amft, Esther Nicole; Dhaun, Neeraj; Luqmani, Raashid A; Little, Mark A; Jayne, David Rw; Flossmann, Oliver; McLaren, John; Kumar, Vinod; Erwig, Lars P; Reid, David M; Jones, Gareth T; Macfarlane, Gary J.

In: Annals of the Rheumatic Diseases, Vol. 73, No. 1, 01.2014, p. 207-11.

Research output: Contribution to journalArticle

Harvard

Basu, N, McClean, A, Harper, L, Amft, EN, Dhaun, N, Luqmani, RA, Little, MA, Jayne, DR, Flossmann, O, McLaren, J, Kumar, V, Erwig, LP, Reid, DM, Jones, GT & Macfarlane, GJ 2014, 'The characterisation and determinants of quality of life in ANCA associated vasculitis', Annals of the Rheumatic Diseases, vol. 73, no. 1, pp. 207-11. https://doi.org/10.1136/annrheumdis-2012-202750

APA

Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., Little, M. A., Jayne, D. R., Flossmann, O., McLaren, J., Kumar, V., Erwig, L. P., Reid, D. M., Jones, G. T., & Macfarlane, G. J. (2014). The characterisation and determinants of quality of life in ANCA associated vasculitis. Annals of the Rheumatic Diseases, 73(1), 207-11. https://doi.org/10.1136/annrheumdis-2012-202750

Vancouver

Author

Basu, Neil ; McClean, Andrew ; Harper, Lorraine ; Amft, Esther Nicole ; Dhaun, Neeraj ; Luqmani, Raashid A ; Little, Mark A ; Jayne, David Rw ; Flossmann, Oliver ; McLaren, John ; Kumar, Vinod ; Erwig, Lars P ; Reid, David M ; Jones, Gareth T ; Macfarlane, Gary J. / The characterisation and determinants of quality of life in ANCA associated vasculitis. In: Annals of the Rheumatic Diseases. 2014 ; Vol. 73, No. 1. pp. 207-11.

Bibtex

@article{656b470372184c948ddb7c2f80d14dfb,
title = "The characterisation and determinants of quality of life in ANCA associated vasculitis",
abstract = "OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV).METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR).RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%).CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.",
keywords = "Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, Anxiety, Case-Control Studies, Chronic Disease, Depression, Fatigue, Female, Humans, Logistic Models, Male, Middle Aged, Quality of Life, Questionnaires, Risk Factors, Sleep Disorders",
author = "Neil Basu and Andrew McClean and Lorraine Harper and Amft, {Esther Nicole} and Neeraj Dhaun and Luqmani, {Raashid A} and Little, {Mark A} and Jayne, {David Rw} and Oliver Flossmann and John McLaren and Vinod Kumar and Erwig, {Lars P} and Reid, {David M} and Jones, {Gareth T} and Macfarlane, {Gary J}",
year = "2014",
month = jan
doi = "10.1136/annrheumdis-2012-202750",
language = "English",
volume = "73",
pages = "207--11",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - The characterisation and determinants of quality of life in ANCA associated vasculitis

AU - Basu, Neil

AU - McClean, Andrew

AU - Harper, Lorraine

AU - Amft, Esther Nicole

AU - Dhaun, Neeraj

AU - Luqmani, Raashid A

AU - Little, Mark A

AU - Jayne, David Rw

AU - Flossmann, Oliver

AU - McLaren, John

AU - Kumar, Vinod

AU - Erwig, Lars P

AU - Reid, David M

AU - Jones, Gareth T

AU - Macfarlane, Gary J

PY - 2014/1

Y1 - 2014/1

N2 - OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV).METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR).RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%).CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

AB - OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV).METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR).RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%).CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

KW - Adult

KW - Aged

KW - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

KW - Antibodies, Antineutrophil Cytoplasmic

KW - Anxiety

KW - Case-Control Studies

KW - Chronic Disease

KW - Depression

KW - Fatigue

KW - Female

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Quality of Life

KW - Questionnaires

KW - Risk Factors

KW - Sleep Disorders

U2 - 10.1136/annrheumdis-2012-202750

DO - 10.1136/annrheumdis-2012-202750

M3 - Article

C2 - 23355077

VL - 73

SP - 207

EP - 211

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 1

ER -