The changing face of haematopoiesis: A spectrum of options is available to stem cells

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The changing face of haematopoiesis: A spectrum of options is available to stem cells. / Brown, Geoffrey; Tsapogas, Panagiotis; Ceredig, Rhodri.

In: Immunology and Cell Biology, 10.04.2018.

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@article{0bbf7716694a44ce854c910bfe855176,
title = "The changing face of haematopoiesis: A spectrum of options is available to stem cells",
abstract = "For more than 30 years, the scheme whereby bone marrow hematopoietic stem cells give rise to the many different types of blood and immune cells has been represented as a lineage tree diagram. In this model, hematopoietic stem cells follow a preferred route to each of the end‐cell types and gradually restrict their other lineage options via a series of intermediate oligo‐potent progenitors. Recent findings of lineage biases or affiliations within hematopoietic stem and progenitor cells that are either pluripotent or uni‐potent show that a continuum of fate options is open to hematopoietic stem cells. These results support the view that in order to close down developmental options, hematopoietic stem cells can make an immediate lineage choice rather than become gradually committed as they progress step‐wise through a series of intermediate progenitors. In this scenario, there is inherent versatility in that developing cells are still able to move sideways to adopt an alternative lineage fate. Here, we examine the information that is leading toward this very different viewpoint of blood cell development.",
author = "Geoffrey Brown and Panagiotis Tsapogas and Rhodri Ceredig",
year = "2018",
month = apr,
day = "10",
doi = "10.1111/imcb.12055",
language = "English",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - The changing face of haematopoiesis: A spectrum of options is available to stem cells

AU - Brown, Geoffrey

AU - Tsapogas, Panagiotis

AU - Ceredig, Rhodri

PY - 2018/4/10

Y1 - 2018/4/10

N2 - For more than 30 years, the scheme whereby bone marrow hematopoietic stem cells give rise to the many different types of blood and immune cells has been represented as a lineage tree diagram. In this model, hematopoietic stem cells follow a preferred route to each of the end‐cell types and gradually restrict their other lineage options via a series of intermediate oligo‐potent progenitors. Recent findings of lineage biases or affiliations within hematopoietic stem and progenitor cells that are either pluripotent or uni‐potent show that a continuum of fate options is open to hematopoietic stem cells. These results support the view that in order to close down developmental options, hematopoietic stem cells can make an immediate lineage choice rather than become gradually committed as they progress step‐wise through a series of intermediate progenitors. In this scenario, there is inherent versatility in that developing cells are still able to move sideways to adopt an alternative lineage fate. Here, we examine the information that is leading toward this very different viewpoint of blood cell development.

AB - For more than 30 years, the scheme whereby bone marrow hematopoietic stem cells give rise to the many different types of blood and immune cells has been represented as a lineage tree diagram. In this model, hematopoietic stem cells follow a preferred route to each of the end‐cell types and gradually restrict their other lineage options via a series of intermediate oligo‐potent progenitors. Recent findings of lineage biases or affiliations within hematopoietic stem and progenitor cells that are either pluripotent or uni‐potent show that a continuum of fate options is open to hematopoietic stem cells. These results support the view that in order to close down developmental options, hematopoietic stem cells can make an immediate lineage choice rather than become gradually committed as they progress step‐wise through a series of intermediate progenitors. In this scenario, there is inherent versatility in that developing cells are still able to move sideways to adopt an alternative lineage fate. Here, we examine the information that is leading toward this very different viewpoint of blood cell development.

U2 - 10.1111/imcb.12055

DO - 10.1111/imcb.12055

M3 - Article

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

SN - 0818-9641

ER -