The challenges of muscle biopsy in a community based geriatric population

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@article{6b5a17c8d45b4ab1b9a0ece82e9f6473,
title = "The challenges of muscle biopsy in a community based geriatric population",
abstract = "ObjectivesTo describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.ResultsForty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considering only muscle mass muscle biopsy would have been successful in 18.7% of the frail older women and 21.4% of the frail older men. In this population, muscle biopsy was not feasible because of contra-indications in the majority of participants. This questions whether a biopsy sample obtained from frail older individuals, is actually representative of this population and supports the need to disclose biopsy failure rate in this population.",
keywords = "Bergstrom needle, Frailty, Percutaneous muscle biopsy, Sarcopenia",
author = "Daisy Wilson and Leigh Breen and Lord, {Janet M.} and Elizabeth Sapey",
year = "2018",
month = nov
day = "26",
doi = "10.1186/s13104-018-3947-8",
language = "English",
volume = "11",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - The challenges of muscle biopsy in a community based geriatric population

AU - Wilson, Daisy

AU - Breen, Leigh

AU - Lord, Janet M.

AU - Sapey, Elizabeth

PY - 2018/11/26

Y1 - 2018/11/26

N2 - ObjectivesTo describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.ResultsForty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considering only muscle mass muscle biopsy would have been successful in 18.7% of the frail older women and 21.4% of the frail older men. In this population, muscle biopsy was not feasible because of contra-indications in the majority of participants. This questions whether a biopsy sample obtained from frail older individuals, is actually representative of this population and supports the need to disclose biopsy failure rate in this population.

AB - ObjectivesTo describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.ResultsForty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considering only muscle mass muscle biopsy would have been successful in 18.7% of the frail older women and 21.4% of the frail older men. In this population, muscle biopsy was not feasible because of contra-indications in the majority of participants. This questions whether a biopsy sample obtained from frail older individuals, is actually representative of this population and supports the need to disclose biopsy failure rate in this population.

KW - Bergstrom needle

KW - Frailty

KW - Percutaneous muscle biopsy

KW - Sarcopenia

U2 - 10.1186/s13104-018-3947-8

DO - 10.1186/s13104-018-3947-8

M3 - Article

C2 - 30477571

VL - 11

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

IS - 1

M1 - 830

ER -