The Cells of the Islets of Langerhans

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The Cells of the Islets of Langerhans. / Da Silva Xavier, Gabriela.

In: Journal of Clinical Medicine, Vol. 7, No. 3, 54, 12.03.2018.

Research output: Contribution to journalReview articlepeer-review

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@article{252feff79a444625aa184175d54594cf,
title = "The Cells of the Islets of Langerhans",
abstract = "Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to help advance such treatment modalities: what should be the target islet/β-cell mass, does islet architecture matter to energy homeostasis, and what may happen if we lose a particular population of islet cells in favour of β-cells? These are all questions to which we will need answers for islet replacement therapy by transdifferentiation of non-β islet cells to be a reality in humans. We know a fair amount about the biology of β-cells but not quite as much about the other islet cell types. Until recently, we have not had a good grasp of islet mass and distribution in the human pancreas. In this review, we will look at current data on islet cells, focussing more on non-β cells, and on human pancreatic islet mass and distribution.",
keywords = "islets of Langerhans, insulin, glucagon, somatostatin, pancreatic polypeptide, ghrelin, pancreas, diabetes, endocrine",
author = "{Da Silva Xavier}, Gabriela",
year = "2018",
month = mar,
day = "12",
doi = "10.3390/jcm7030054",
language = "English",
volume = "7",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "MDPI",
number = "3",

}

RIS

TY - JOUR

T1 - The Cells of the Islets of Langerhans

AU - Da Silva Xavier, Gabriela

PY - 2018/3/12

Y1 - 2018/3/12

N2 - Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to help advance such treatment modalities: what should be the target islet/β-cell mass, does islet architecture matter to energy homeostasis, and what may happen if we lose a particular population of islet cells in favour of β-cells? These are all questions to which we will need answers for islet replacement therapy by transdifferentiation of non-β islet cells to be a reality in humans. We know a fair amount about the biology of β-cells but not quite as much about the other islet cell types. Until recently, we have not had a good grasp of islet mass and distribution in the human pancreas. In this review, we will look at current data on islet cells, focussing more on non-β cells, and on human pancreatic islet mass and distribution.

AB - Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to help advance such treatment modalities: what should be the target islet/β-cell mass, does islet architecture matter to energy homeostasis, and what may happen if we lose a particular population of islet cells in favour of β-cells? These are all questions to which we will need answers for islet replacement therapy by transdifferentiation of non-β islet cells to be a reality in humans. We know a fair amount about the biology of β-cells but not quite as much about the other islet cell types. Until recently, we have not had a good grasp of islet mass and distribution in the human pancreas. In this review, we will look at current data on islet cells, focussing more on non-β cells, and on human pancreatic islet mass and distribution.

KW - islets of Langerhans

KW - insulin

KW - glucagon

KW - somatostatin

KW - pancreatic polypeptide

KW - ghrelin

KW - pancreas

KW - diabetes

KW - endocrine

U2 - 10.3390/jcm7030054

DO - 10.3390/jcm7030054

M3 - Review article

C2 - 29534517

VL - 7

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 3

M1 - 54

ER -