The causes of the metabolic syndrome: An Asian perspective

Research output: Chapter in Book/Report/Conference proceedingChapter


Colleges, School and Institutes

External organisations

  • School of Clinical and Experimental Medicine
  • CDSC (West Midlands)


Due to urbanization and economic development, the metabolic syndrome has become prevalent in Asia and will be an important risk factor for cardiovascular diseases. Overeating and lack of physical activity lead to central obesity, the metabolic syndrome and cardiovascular diseases. Excess fat increases fatty acids in the blood, and also causes local and widespread inflammation. This inflammation is harmful to blood vessels and leads to endothelial dysfunction, high blood pressure and atherosclerosis. Lifestyle modification is the key to preventing the metabolic syndrome. Metformin, acarbose and glitazones may help to prevent the development of diabetes. Orlistat has a limited role for treating obesity, but there are new drugs for obesity in the pipeline.


Original languageEnglish
Title of host publicationLife Sciences of the Asia Pacific Region
Publication statusPublished - 1 Dec 2012


  • Asians, Cardiovascular disease, Diabetes, Lipids, Metabolic syndrome, Obesity

ASJC Scopus subject areas