The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK

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The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK. / Parker, Laura; Turner, Grace; Roberts, Lesley M; McCahon, Deborah; Turner, Grace; Calvert, Melanie.

In: Family Practice, Vol. 31, No. 5, 10.2014, p. 557-563.

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@article{425f0d8c9243423a90dcb5b2a6fb830e,
title = "The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK",
abstract = "BACKGROUND: Given the high prevalence of chronic conditions and multimorbidity in the elderly, there is a need to determine which chronic conditions have the greatest impact on health-related quality of life (HRQL) and identify where additional intervention may be required.OBJECTIVE: To explore the impact of a range of common chronic conditions on HRQL in a community-based population aged 65 years or more in the UK.METHODS: Secondary analysis of data derived from a large (n = 5849) cross-sectional study. HRQL was assessed using the EuroQoL EQ-5D. Multivariable models were used to estimate the relative effect of 15 individual common chronic conditions and combinations of these conditions on HRQL.RESULTS: Mean age of participants was 74.6 years, 49.2% were male. The mean EQ-5D index score was 0.78 (standard deviation 0.2), range -0.43 to 1.00. Overall, 53% (n = 3078) of the cohort reported problems with pain, 39% (n = 2273) with mobility and 9% (n = 529) with self-care. Multivariate modelling demonstrated that impaired HRQL was significantly associated with 13 of the 15 common chronic conditions studied. Clinically meaningful reductions in EQ-5D index scores were observed for osteoarthritis (-0.081, P = 0.0006), neurological disease (-0.172, P < 0.0001) and depression (-0.269, P < 0.001).CONCLUSIONS: This study quantifies the relative impact of 13 common chronic conditions on HRQL in a UK-based community-dwelling ageing population. Findings indicate that osteoarthritis, depression and neurological disease have a strong clinically important negative effect on HRQL. These findings may help clinical decision making and priority setting for management of individuals with multimorbidity.",
keywords = "Aged, Aged, 80 and over, Chronic Disease, Chronic Pain, Cost of Illness, Cross-Sectional Studies, Depression, Female, Great Britain, Humans, Independent Living, Male, Middle Aged, Mobility Limitation, Nervous System Diseases, Osteoarthritis, Quality of Life, Questionnaires, Self Care",
author = "Laura Parker and Grace Turner and Roberts, {Lesley M} and Deborah McCahon and Grace Turner and Melanie Calvert",
note = "{\textcopyright} The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2014",
month = oct,
doi = "10.1093/fampra/cmu035",
language = "English",
volume = "31",
pages = "557--563",
journal = "Family Practice",
issn = "0263-2136",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK

AU - Parker, Laura

AU - Turner, Grace

AU - Roberts, Lesley M

AU - McCahon, Deborah

AU - Turner, Grace

AU - Calvert, Melanie

N1 - © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2014/10

Y1 - 2014/10

N2 - BACKGROUND: Given the high prevalence of chronic conditions and multimorbidity in the elderly, there is a need to determine which chronic conditions have the greatest impact on health-related quality of life (HRQL) and identify where additional intervention may be required.OBJECTIVE: To explore the impact of a range of common chronic conditions on HRQL in a community-based population aged 65 years or more in the UK.METHODS: Secondary analysis of data derived from a large (n = 5849) cross-sectional study. HRQL was assessed using the EuroQoL EQ-5D. Multivariable models were used to estimate the relative effect of 15 individual common chronic conditions and combinations of these conditions on HRQL.RESULTS: Mean age of participants was 74.6 years, 49.2% were male. The mean EQ-5D index score was 0.78 (standard deviation 0.2), range -0.43 to 1.00. Overall, 53% (n = 3078) of the cohort reported problems with pain, 39% (n = 2273) with mobility and 9% (n = 529) with self-care. Multivariate modelling demonstrated that impaired HRQL was significantly associated with 13 of the 15 common chronic conditions studied. Clinically meaningful reductions in EQ-5D index scores were observed for osteoarthritis (-0.081, P = 0.0006), neurological disease (-0.172, P < 0.0001) and depression (-0.269, P < 0.001).CONCLUSIONS: This study quantifies the relative impact of 13 common chronic conditions on HRQL in a UK-based community-dwelling ageing population. Findings indicate that osteoarthritis, depression and neurological disease have a strong clinically important negative effect on HRQL. These findings may help clinical decision making and priority setting for management of individuals with multimorbidity.

AB - BACKGROUND: Given the high prevalence of chronic conditions and multimorbidity in the elderly, there is a need to determine which chronic conditions have the greatest impact on health-related quality of life (HRQL) and identify where additional intervention may be required.OBJECTIVE: To explore the impact of a range of common chronic conditions on HRQL in a community-based population aged 65 years or more in the UK.METHODS: Secondary analysis of data derived from a large (n = 5849) cross-sectional study. HRQL was assessed using the EuroQoL EQ-5D. Multivariable models were used to estimate the relative effect of 15 individual common chronic conditions and combinations of these conditions on HRQL.RESULTS: Mean age of participants was 74.6 years, 49.2% were male. The mean EQ-5D index score was 0.78 (standard deviation 0.2), range -0.43 to 1.00. Overall, 53% (n = 3078) of the cohort reported problems with pain, 39% (n = 2273) with mobility and 9% (n = 529) with self-care. Multivariate modelling demonstrated that impaired HRQL was significantly associated with 13 of the 15 common chronic conditions studied. Clinically meaningful reductions in EQ-5D index scores were observed for osteoarthritis (-0.081, P = 0.0006), neurological disease (-0.172, P < 0.0001) and depression (-0.269, P < 0.001).CONCLUSIONS: This study quantifies the relative impact of 13 common chronic conditions on HRQL in a UK-based community-dwelling ageing population. Findings indicate that osteoarthritis, depression and neurological disease have a strong clinically important negative effect on HRQL. These findings may help clinical decision making and priority setting for management of individuals with multimorbidity.

KW - Aged

KW - Aged, 80 and over

KW - Chronic Disease

KW - Chronic Pain

KW - Cost of Illness

KW - Cross-Sectional Studies

KW - Depression

KW - Female

KW - Great Britain

KW - Humans

KW - Independent Living

KW - Male

KW - Middle Aged

KW - Mobility Limitation

KW - Nervous System Diseases

KW - Osteoarthritis

KW - Quality of Life

KW - Questionnaires

KW - Self Care

U2 - 10.1093/fampra/cmu035

DO - 10.1093/fampra/cmu035

M3 - Article

C2 - 24987022

VL - 31

SP - 557

EP - 563

JO - Family Practice

JF - Family Practice

SN - 0263-2136

IS - 5

ER -