The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder

S Cohen-Woods; I Craig; D Gaysina; J Gray; C Gunasinghe; N Craddock; A Elkin; Lisa Jones; J Kennedy; N King; A Korszun; J Knight; M Owen; S Parikh; J Strauss; A Sterne; F Tozzi; J Perry; P Muglia; J Vincent; P McGuffin; A Farmer

doi:10.1002/ajmg.b.31101

The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder

S Cohen-Woods, I Craig, D Gaysina, J Gray, C Gunasinghe, N Craddock, A Elkin, Lisa Jones, J Kennedy, N King, A Korszun, J Knight, M Owen, S Parikh, J Strauss, A Sterne, F Tozzi, J Perry, P Muglia, J VincentP McGuffin, A Farmer

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. (c) 2010 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	1298-1304
Number of pages	7
Journal	American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume	153B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31101
Publication status	Published - 1 Oct 2010

Keywords

genetics
MTHFR
bipolar disorder
mood disorder
manic depression

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Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., ... Farmer, A. (2010). The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B(7), 1298-1304. https://doi.org/10.1002/ajmg.b.31101

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abstract = "Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. (c) 2010 Wiley-Liss, Inc.",

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author = "S Cohen-Woods and I Craig and D Gaysina and J Gray and C Gunasinghe and N Craddock and A Elkin and Lisa Jones and J Kennedy and N King and A Korszun and J Knight and M Owen and S Parikh and J Strauss and A Sterne and F Tozzi and J Perry and P Muglia and J Vincent and P McGuffin and A Farmer",

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Cohen-Woods, S, Craig, I, Gaysina, D, Gray, J, Gunasinghe, C, Craddock, N, Elkin, A, Jones, L, Kennedy, J, King, N, Korszun, A, Knight, J, Owen, M, Parikh, S, Strauss, J, Sterne, A, Tozzi, F, Perry, J, Muglia, P, Vincent, J, McGuffin, P & Farmer, A 2010, 'The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 153B, no. 7, pp. 1298-1304. https://doi.org/10.1002/ajmg.b.31101

The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder. / Cohen-Woods, S; Craig, I; Gaysina, D et al.
In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 153B, No. 7, 01.10.2010, p. 1298-1304.

Research output: Contribution to journal › Article

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T1 - The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder

AU - Cohen-Woods, S

AU - Craig, I

AU - Gaysina, D

AU - Gray, J

AU - Gunasinghe, C

AU - Craddock, N

AU - Elkin, A

AU - Jones, Lisa

AU - Kennedy, J

AU - King, N

AU - Korszun, A

AU - Knight, J

AU - Owen, M

AU - Parikh, S

AU - Strauss, J

AU - Sterne, A

AU - Tozzi, F

AU - Perry, J

AU - Muglia, P

AU - Vincent, J

AU - McGuffin, P

AU - Farmer, A

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N2 - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. (c) 2010 Wiley-Liss, Inc.

AB - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. (c) 2010 Wiley-Liss, Inc.

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KW - MTHFR

KW - bipolar disorder

KW - mood disorder

KW - manic depression

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DO - 10.1002/ajmg.b.31101

M3 - Article

VL - 153B

SP - 1298

EP - 1304

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

IS - 7

ER -

The Bipolar Association Case-Control Study (BACCS) and Meta-Analysis: No Association With the 5,10-Methylenetetrahydrofolate Reductase Gene and Bipolar Disorder

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Keywords

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