The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus

E M Hay; P A Bacon; C Gordon; D A Isenberg; P Maddison; M L Snaith; D P Symmons; N Viner; A Zoma

The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus

E M Hay, P A Bacon, C Gordon, D A Isenberg, P Maddison, M L Snaith, D P Symmons, N Viner, A Zoma

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

497 Citations (Scopus)

Abstract

The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the principle of the physician's 'intention to treat'. The index allocates separate alphabetic scores to each of eight organ-based systems; a total score is not calculated. This study demonstrated good between-rater reliability for the BILAG index for each organ-based system. There was no evidence of bias between observers. The BILAG index had good overall sensitivity (87%) and specificity (99%) when compared with the 'gold standard' criterion (starting or increasing disease-modifying therapy). There were high positive predictive values overall (80%), and for each organ-based system, with the exception of the neurological system.

Original language	English
Pages (from-to)	447-58
Number of pages	12
Journal	QJM
Volume	86
Issue number	7
Publication status	Published - Jul 1993

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Child
Diagnosis, Computer-Assisted
Female
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index

Cite this

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title = "The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus",

abstract = "The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the principle of the physician's 'intention to treat'. The index allocates separate alphabetic scores to each of eight organ-based systems; a total score is not calculated. This study demonstrated good between-rater reliability for the BILAG index for each organ-based system. There was no evidence of bias between observers. The BILAG index had good overall sensitivity (87%) and specificity (99%) when compared with the 'gold standard' criterion (starting or increasing disease-modifying therapy). There were high positive predictive values overall (80%), and for each organ-based system, with the exception of the neurological system.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Diagnosis, Computer-Assisted, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index",

author = "Hay, {E M} and Bacon, {P A} and C Gordon and Isenberg, {D A} and P Maddison and Snaith, {M L} and Symmons, {D P} and N Viner and A Zoma",

year = "1993",

month = jul,

language = "English",

volume = "86",

pages = "447--58",

journal = "QJM",

issn = "1460-2725",

publisher = "Oxford University Press",

number = "7",

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TY - JOUR

T1 - The BILAG index

T2 - a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus

AU - Hay, E M

AU - Bacon, P A

AU - Gordon, C

AU - Isenberg, D A

AU - Maddison, P

AU - Snaith, M L

AU - Symmons, D P

AU - Viner, N

AU - Zoma, A

PY - 1993/7

Y1 - 1993/7

N2 - The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the principle of the physician's 'intention to treat'. The index allocates separate alphabetic scores to each of eight organ-based systems; a total score is not calculated. This study demonstrated good between-rater reliability for the BILAG index for each organ-based system. There was no evidence of bias between observers. The BILAG index had good overall sensitivity (87%) and specificity (99%) when compared with the 'gold standard' criterion (starting or increasing disease-modifying therapy). There were high positive predictive values overall (80%), and for each organ-based system, with the exception of the neurological system.

AB - The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the principle of the physician's 'intention to treat'. The index allocates separate alphabetic scores to each of eight organ-based systems; a total score is not calculated. This study demonstrated good between-rater reliability for the BILAG index for each organ-based system. There was no evidence of bias between observers. The BILAG index had good overall sensitivity (87%) and specificity (99%) when compared with the 'gold standard' criterion (starting or increasing disease-modifying therapy). There were high positive predictive values overall (80%), and for each organ-based system, with the exception of the neurological system.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Diagnosis, Computer-Assisted

KW - Female

KW - Humans

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Severity of Illness Index

M3 - Article

C2 - 8210301

SN - 1460-2725

VL - 86

SP - 447

EP - 458

JO - QJM

JF - QJM

IS - 7

ER -

The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus

Abstract

Keywords

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