The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

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@article{b9e0cb4ea49544149e137254ec2b9365,
title = "The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals",
abstract = "A genetic variant of the leukocyte phosphatase PTPN22 (R620W) is strongly associated with autoimmune diseases including rheumatoid arthritis (RA). Functional studies on the variant have focussed on lymphocytes, but it is most highly expressed in neutrophils. We have investigated the effects of the variant on neutrophil function in health and in patients with RA.",
keywords = "Autoimmune Diseases, Gene Polymorphism, Rheumatoid Arthritis",
author = "Rachel Bayley and Kite, {Kerry A} and McGettrick, {Helen M} and Smith, {Jacqueline P} and Kitas, {George D} and Buckley, {Christopher D} and Young, {Stephen P}",
note = "Accepted 1 March 2014",
year = "2015",
doi = "10.1136/annrheumdis-2013-204796",
language = "English",
volume = "74",
pages = "1588--95",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

AU - Bayley, Rachel

AU - Kite, Kerry A

AU - McGettrick, Helen M

AU - Smith, Jacqueline P

AU - Kitas, George D

AU - Buckley, Christopher D

AU - Young, Stephen P

N1 - Accepted 1 March 2014

PY - 2015

Y1 - 2015

N2 - A genetic variant of the leukocyte phosphatase PTPN22 (R620W) is strongly associated with autoimmune diseases including rheumatoid arthritis (RA). Functional studies on the variant have focussed on lymphocytes, but it is most highly expressed in neutrophils. We have investigated the effects of the variant on neutrophil function in health and in patients with RA.

AB - A genetic variant of the leukocyte phosphatase PTPN22 (R620W) is strongly associated with autoimmune diseases including rheumatoid arthritis (RA). Functional studies on the variant have focussed on lymphocytes, but it is most highly expressed in neutrophils. We have investigated the effects of the variant on neutrophil function in health and in patients with RA.

KW - Autoimmune Diseases

KW - Gene Polymorphism

KW - Rheumatoid Arthritis

U2 - 10.1136/annrheumdis-2013-204796

DO - 10.1136/annrheumdis-2013-204796

M3 - Article

C2 - 24665115

VL - 74

SP - 1588

EP - 1595

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 8

ER -