The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

Rachel Bayley; Kerry A Kite; Helen M McGettrick; Jacqueline P Smith; George D Kitas; Christopher D Buckley; Stephen P Young

doi:10.1136/annrheumdis-2013-204796

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

Rachel Bayley, Kerry A Kite, Helen M McGettrick, Jacqueline P Smith, George D Kitas, Christopher D Buckley, Stephen P Young

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Abstract

A genetic variant of the leukocyte phosphatase PTPN22 (R620W) is strongly associated with autoimmune diseases including rheumatoid arthritis (RA). Functional studies on the variant have focussed on lymphocytes, but it is most highly expressed in neutrophils. We have investigated the effects of the variant on neutrophil function in health and in patients with RA.

Original language	English
Pages (from-to)	1588-95
Journal	Annals of the Rheumatic Diseases
Volume	74
Issue number	8
Early online date	24 Mar 2014
DOIs	https://doi.org/10.1136/annrheumdis-2013-204796
Publication status	Published - 2015

Bibliographical note

Accepted 1 March 2014

Keywords

Autoimmune Diseases
Gene Polymorphism
Rheumatoid Arthritis

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10.1136/annrheumdis-2013-204796

PTPN22 Neutrophils Paper revised all
Eligibility for repository : checked 09/06/2014
Accepted author manuscript, 409 KBLicence: None: All rights reserved

Exploring the Role of Synovial Fibroblasts in Regulating Leukocyte Accumulation During the Development of Persistent Arthritis
McGettrick, H.
ARTHRITIS RESEARCH CAMPAIGN
6/06/12 → 5/06/17
Project: Research

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Bayley, R., Kite, K. A., McGettrick, H. M., Smith, J. P., Kitas, G. D., Buckley, C. D., & Young, S. P. (2015). The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. Annals of the Rheumatic Diseases, 74(8), 1588-95. Advance online publication. https://doi.org/10.1136/annrheumdis-2013-204796

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abstract = "A genetic variant of the leukocyte phosphatase PTPN22 (R620W) is strongly associated with autoimmune diseases including rheumatoid arthritis (RA). Functional studies on the variant have focussed on lymphocytes, but it is most highly expressed in neutrophils. We have investigated the effects of the variant on neutrophil function in health and in patients with RA.",

keywords = "Autoimmune Diseases, Gene Polymorphism, Rheumatoid Arthritis",

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AU - Kitas, George D

AU - Buckley, Christopher D

AU - Young, Stephen P

N1 - Accepted 1 March 2014

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KW - Gene Polymorphism

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The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

Abstract

Bibliographical note

Keywords

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Projects

Exploring the Role of Synovial Fibroblasts in Regulating Leukocyte Accumulation During the Development of Persistent Arthritis

Cite this