The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

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The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. / Bose, Shikha; Yap, LF; Fung, Matthew; Starzcynski, J; Saleh, A; Morgan, S; Dawson, Christopher; Chukwuma, MB; Maina, E; Buettner, M; Wei, Wenbin; Arrand, John; Lim, PV; Young, Lawrence; Teo, SH; Stankovic, Tatjana; Woodman, Ciaran; Murray, Paul.

In: Journal of Pathology, Vol. 217, No. 3, 01.02.2009, p. 345-52.

Research output: Contribution to journalArticle

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Bose, S, Yap, LF, Fung, M, Starzcynski, J, Saleh, A, Morgan, S, Dawson, C, Chukwuma, MB, Maina, E, Buettner, M, Wei, W, Arrand, J, Lim, PV, Young, L, Teo, SH, Stankovic, T, Woodman, C & Murray, P 2009, 'The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.', Journal of Pathology, vol. 217, no. 3, pp. 345-52. https://doi.org/10.1002/path.2487

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Author

Bose, Shikha ; Yap, LF ; Fung, Matthew ; Starzcynski, J ; Saleh, A ; Morgan, S ; Dawson, Christopher ; Chukwuma, MB ; Maina, E ; Buettner, M ; Wei, Wenbin ; Arrand, John ; Lim, PV ; Young, Lawrence ; Teo, SH ; Stankovic, Tatjana ; Woodman, Ciaran ; Murray, Paul. / The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. In: Journal of Pathology. 2009 ; Vol. 217, No. 3. pp. 345-52.

Bibtex

@article{2c9018dd790b429e9b0b7651c480b4a3,
title = "The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.",
abstract = "A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.",
keywords = "Epstein-Barr virus, nasopharyngeal carcinoma, ATM",
author = "Shikha Bose and LF Yap and Matthew Fung and J Starzcynski and A Saleh and S Morgan and Christopher Dawson and MB Chukwuma and E Maina and M Buettner and Wenbin Wei and John Arrand and PV Lim and Lawrence Young and SH Teo and Tatjana Stankovic and Ciaran Woodman and Paul Murray",
year = "2009",
month = feb,
day = "1",
doi = "10.1002/path.2487",
language = "English",
volume = "217",
pages = "345--52",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

AU - Bose, Shikha

AU - Yap, LF

AU - Fung, Matthew

AU - Starzcynski, J

AU - Saleh, A

AU - Morgan, S

AU - Dawson, Christopher

AU - Chukwuma, MB

AU - Maina, E

AU - Buettner, M

AU - Wei, Wenbin

AU - Arrand, John

AU - Lim, PV

AU - Young, Lawrence

AU - Teo, SH

AU - Stankovic, Tatjana

AU - Woodman, Ciaran

AU - Murray, Paul

PY - 2009/2/1

Y1 - 2009/2/1

N2 - A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.

AB - A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.

KW - Epstein-Barr virus

KW - nasopharyngeal carcinoma

KW - ATM

U2 - 10.1002/path.2487

DO - 10.1002/path.2487

M3 - Article

C2 - 19142888

VL - 217

SP - 345

EP - 352

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 3

ER -